Associations with photoreceptor thickness measures in the UK Biobank

UK Biobank Eye and Vision Consortium, Sharon Y. L. Chua, Baljean Dhillon, Tariq Aslam, Konstantinos Balaskas, Qi Yang, Pearse A. Keane, Adnan Tufail, Charles Reisman, Paul J. Foster, Praveen J Patel (Lead / Corresponding author)

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Abstract

Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40-69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.

Original languageEnglish
Article number19440
Pages (from-to)1-14
Number of pages14
JournalScientific Reports
Volume9
DOIs
Publication statusPublished - 19 Dec 2019

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Retinal Pigment Epithelium
Refractive Errors
Membranes
Smoking
Blood Pressure
Physical Examination
Hypertension

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UK Biobank Eye and Vision Consortium, Chua, S. Y. L., Dhillon, B., Aslam, T., Balaskas, K., Yang, Q., ... Patel, P. J. (2019). Associations with photoreceptor thickness measures in the UK Biobank. Scientific Reports, 9, 1-14. [19440]. https://doi.org/10.1038/s41598-019-55484-1
UK Biobank Eye and Vision Consortium ; Chua, Sharon Y. L. ; Dhillon, Baljean ; Aslam, Tariq ; Balaskas, Konstantinos ; Yang, Qi ; Keane, Pearse A. ; Tufail, Adnan ; Reisman, Charles ; Foster, Paul J. ; Patel, Praveen J. / Associations with photoreceptor thickness measures in the UK Biobank. In: Scientific Reports. 2019 ; Vol. 9. pp. 1-14.
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abstract = "Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40-69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.",
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UK Biobank Eye and Vision Consortium, Chua, SYL, Dhillon, B, Aslam, T, Balaskas, K, Yang, Q, Keane, PA, Tufail, A, Reisman, C, Foster, PJ & Patel, PJ 2019, 'Associations with photoreceptor thickness measures in the UK Biobank', Scientific Reports, vol. 9, 19440, pp. 1-14. https://doi.org/10.1038/s41598-019-55484-1

Associations with photoreceptor thickness measures in the UK Biobank. / UK Biobank Eye and Vision Consortium; Chua, Sharon Y. L.; Dhillon, Baljean; Aslam, Tariq; Balaskas, Konstantinos; Yang, Qi; Keane, Pearse A.; Tufail, Adnan; Reisman, Charles; Foster, Paul J.; Patel, Praveen J (Lead / Corresponding author).

In: Scientific Reports, Vol. 9, 19440, 19.12.2019, p. 1-14.

Research output: Contribution to journalArticle

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AU - Chua, Sharon Y. L.

AU - Dhillon, Baljean

AU - Aslam, Tariq

AU - Balaskas, Konstantinos

AU - Yang, Qi

AU - Keane, Pearse A.

AU - Tufail, Adnan

AU - Reisman, Charles

AU - Foster, Paul J.

AU - Patel, Praveen J

AU - Trucco, Manuel

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N2 - Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40-69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.

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UK Biobank Eye and Vision Consortium, Chua SYL, Dhillon B, Aslam T, Balaskas K, Yang Q et al. Associations with photoreceptor thickness measures in the UK Biobank. Scientific Reports. 2019 Dec 19;9:1-14. 19440. https://doi.org/10.1038/s41598-019-55484-1