Associative learning and the genetics of schizophrenia

Jeremy Hall; Liana Romaniuk; Andrew M. McIntosh; J. Douglas Steele; Eve C. Johnstone; Stephen M. Lawrie

doi:10.1016/j.tins.2009.01.011

Associative learning and the genetics of schizophrenia

Jeremy Hall, Liana Romaniuk, Andrew M. McIntosh, J. Douglas Steele, Eve C. Johnstone, Stephen M. Lawrie

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

Abstract

Several well-validated susceptibility genes for schizophrenia have now been identified. We suggest that these genes can be divided into two broad classes. Those in the first class have direct effects on synaptic plasticity mediated through actions at glutamatergic synapses; those in the second class impact on meso-limbic dopamine signalling. We argue that these genes have an interactive effect on risk for psychosis and that this interaction can be understood in the context of associative learning theory. We illustrate how genetic variation in genes from these classes can contribute to the development of psychosis using data from the Edinburgh High Risk Study of schizophrenia.

Original language	English
Pages (from-to)	359-365
Number of pages	7
Journal	Trends in Neurosciences
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/j.tins.2009.01.011
Publication status	Published - Jun 2009

Keywords

CATECHOL-O-METHYLTRANSFERASE
LONG-TERM POTENTIATION
PREDICTION-ERROR
INCENTIVE SALIENCE
SYNAPTIC PLASTICITY
REWARD PREDICTION
BRAIN STRUCTURE
NMDA RECEPTORS
HIGH-RISK
DOPAMINE

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title = "Associative learning and the genetics of schizophrenia",

abstract = "Several well-validated susceptibility genes for schizophrenia have now been identified. We suggest that these genes can be divided into two broad classes. Those in the first class have direct effects on synaptic plasticity mediated through actions at glutamatergic synapses; those in the second class impact on meso-limbic dopamine signalling. We argue that these genes have an interactive effect on risk for psychosis and that this interaction can be understood in the context of associative learning theory. We illustrate how genetic variation in genes from these classes can contribute to the development of psychosis using data from the Edinburgh High Risk Study of schizophrenia.",

keywords = "CATECHOL-O-METHYLTRANSFERASE, LONG-TERM POTENTIATION, PREDICTION-ERROR, INCENTIVE SALIENCE, SYNAPTIC PLASTICITY, REWARD PREDICTION, BRAIN STRUCTURE, NMDA RECEPTORS, HIGH-RISK, DOPAMINE",

author = "Jeremy Hall and Liana Romaniuk and McIntosh, {Andrew M.} and Steele, {J. Douglas} and Johnstone, {Eve C.} and Lawrie, {Stephen M.}",

year = "2009",

month = jun,

doi = "10.1016/j.tins.2009.01.011",

language = "English",

volume = "32",

pages = "359--365",

journal = "Trends in Neurosciences",

issn = "0166-2236",

publisher = "Elsevier",

number = "6",

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TY - JOUR

T1 - Associative learning and the genetics of schizophrenia

AU - Hall, Jeremy

AU - Romaniuk, Liana

AU - McIntosh, Andrew M.

AU - Steele, J. Douglas

AU - Johnstone, Eve C.

AU - Lawrie, Stephen M.

PY - 2009/6

Y1 - 2009/6

N2 - Several well-validated susceptibility genes for schizophrenia have now been identified. We suggest that these genes can be divided into two broad classes. Those in the first class have direct effects on synaptic plasticity mediated through actions at glutamatergic synapses; those in the second class impact on meso-limbic dopamine signalling. We argue that these genes have an interactive effect on risk for psychosis and that this interaction can be understood in the context of associative learning theory. We illustrate how genetic variation in genes from these classes can contribute to the development of psychosis using data from the Edinburgh High Risk Study of schizophrenia.

AB - Several well-validated susceptibility genes for schizophrenia have now been identified. We suggest that these genes can be divided into two broad classes. Those in the first class have direct effects on synaptic plasticity mediated through actions at glutamatergic synapses; those in the second class impact on meso-limbic dopamine signalling. We argue that these genes have an interactive effect on risk for psychosis and that this interaction can be understood in the context of associative learning theory. We illustrate how genetic variation in genes from these classes can contribute to the development of psychosis using data from the Edinburgh High Risk Study of schizophrenia.

KW - CATECHOL-O-METHYLTRANSFERASE

KW - LONG-TERM POTENTIATION

KW - PREDICTION-ERROR

KW - INCENTIVE SALIENCE

KW - SYNAPTIC PLASTICITY

KW - REWARD PREDICTION

KW - BRAIN STRUCTURE

KW - NMDA RECEPTORS

KW - HIGH-RISK

KW - DOPAMINE

U2 - 10.1016/j.tins.2009.01.011

DO - 10.1016/j.tins.2009.01.011

M3 - Review article

C2 - 19427043

SN - 0166-2236

VL - 32

SP - 359

EP - 365

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 6

ER -

Associative learning and the genetics of schizophrenia

Abstract

Keywords

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