TY - JOUR
T1 - Asymmetric midshaft femur remodeling in an adult male with left sided hip joint ankylosis, Metal Period Nagsabaran, Philippines
AU - Miszkiewicz, Justyna J.
AU - Rider, Claire
AU - Kealy, Shimona
AU - Vrahnas, Christina
AU - Sims, Natalie A.
AU - Vongsvivut, Jitraporn
AU - Tobin, Mark J.
AU - Bolunia, Mary Jane Louise A.
AU - De Leon, Alexandra S.
AU - Peñalosa, Antonio L.
AU - Pagulayan, Pablo S.
AU - Soriano, Adan V.
AU - Page, Ruth
AU - Oxenham, Marc F.
N1 - This study is a result of a long-term collaboration between the National Museum of the Philippines (NMP) and the Australian National University (ANU). Funding for this study was received from the Australian Research Council (DE190100068) andANU CASS(microscopy equipment). ANU RSHA 2017 travel grant facilitated stay on-site at the ANSTO – Australian Synchrotron facility (Clayton, Victoria).
PY - 2020/12
Y1 - 2020/12
N2 - Objective: This study investigated microstructural changes of the right and left midshaft femur in an archaeological individual afflicted with left-sided hip joint ankylosis to assess whether increased cortical porosity was present as a result of leg disuse.Materials: The individual is a middle-aged adult male excavated from the Metal Period (∼2000 BP) Nagsabaran, Luzon Island, Philippines.Methods: Following standard examination of femur gross anatomy and differential diagnosis of the hip joint fusion, ∼1 cm thick posterior midshaft femur samples were removed for microstructural examination. Using static histomorphometry, bone multi-cellular unit activity from Haversian canal (vascular pore) density, area, and circularity was reconstructed. Spatial positioning of Haversian canals was mapped using Geographic Information Systems software. Phosphate, carbonate, and carbonate:phosphate ratios were obtained using synchrotron-sourced Fourier transform infrared microspectroscopy.Results: The left femur had greater cortical pore density, with smaller and rounder vascular canals, in addition to lower matrix levels of phosphate and carbonate, when compared to the right femur.Conclusions: Our data indicate compromised bone tissue in the left femur, and conform to expected bone functional adaptation paradigms of remodeling responses to pathological and biomechanical changes.Significance: The preservation of this individual's hip abnormality created a unique opportunity to evaluate intra-skeletal bone health asymmetry, which may help other researchers evaluate the presence of limb disuse in archaeological samples.Limitations: A lack of lower limb data limits our interpretations to femur remodeling only.Suggestions for Further Research: Future research efforts should aim to examine the presence of remodeling changes in all bones of the lower limb.
AB - Objective: This study investigated microstructural changes of the right and left midshaft femur in an archaeological individual afflicted with left-sided hip joint ankylosis to assess whether increased cortical porosity was present as a result of leg disuse.Materials: The individual is a middle-aged adult male excavated from the Metal Period (∼2000 BP) Nagsabaran, Luzon Island, Philippines.Methods: Following standard examination of femur gross anatomy and differential diagnosis of the hip joint fusion, ∼1 cm thick posterior midshaft femur samples were removed for microstructural examination. Using static histomorphometry, bone multi-cellular unit activity from Haversian canal (vascular pore) density, area, and circularity was reconstructed. Spatial positioning of Haversian canals was mapped using Geographic Information Systems software. Phosphate, carbonate, and carbonate:phosphate ratios were obtained using synchrotron-sourced Fourier transform infrared microspectroscopy.Results: The left femur had greater cortical pore density, with smaller and rounder vascular canals, in addition to lower matrix levels of phosphate and carbonate, when compared to the right femur.Conclusions: Our data indicate compromised bone tissue in the left femur, and conform to expected bone functional adaptation paradigms of remodeling responses to pathological and biomechanical changes.Significance: The preservation of this individual's hip abnormality created a unique opportunity to evaluate intra-skeletal bone health asymmetry, which may help other researchers evaluate the presence of limb disuse in archaeological samples.Limitations: A lack of lower limb data limits our interpretations to femur remodeling only.Suggestions for Further Research: Future research efforts should aim to examine the presence of remodeling changes in all bones of the lower limb.
KW - Carbonate
KW - Histology
KW - Joint stiffness
KW - Phosphate
UR - http://www.scopus.com/inward/record.url?scp=85089949216&partnerID=8YFLogxK
U2 - 10.1016/j.ijpp.2020.07.003
DO - 10.1016/j.ijpp.2020.07.003
M3 - Article
C2 - 32877865
AN - SCOPUS:85089949216
SN - 1879-9817
VL - 31
SP - 14
EP - 22
JO - International Journal of Paleopathology
JF - International Journal of Paleopathology
ER -