At last, a predictive and prognostic marker for radiotherapy?

Philip Coates, John Dewar, Alastair M. Thompson

    Research output: Contribution to journalEditorialpeer-review

    6 Citations (Scopus)

    Abstract

    Holliday junction recognition protein (HJURP) levels in breast cancer associate with both poor prognosis and an increased sensitivity to irradiation. Whilst, in part, this could be explained in relation to proliferation, it would not entirely account for the association with sensitivity to radiation. Thus, HJURP may have clinical potential as a marker of prognosis and radiation sensitivity; further validation with tissues from randomised controlled trials is needed. HJURP may represent the first in a class of proteins with roles in chromosome segregation and DNA repair that act as predictive biomarkers.

    Original languageEnglish
    Article number106
    Pages (from-to)-
    Number of pages2
    JournalBreast Cancer Research
    Volume12
    Issue number3
    DOIs
    Publication statusPublished - 2010

    Keywords

    • EARLY BREAST-CANCER
    • CENP-A
    • UK STANDARDIZATION
    • RANDOMIZED-TRIAL
    • HJURP
    • HYPOFRACTIONATION
    • RADIATION

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