Athena: Speciality Certificate Examination case for Dermatopathology

TY - JOUR

T1 - Athena

T2 - Speciality Certificate Examination case for Dermatopathology

AU - Sheppeard, R.

AU - Dubash, F.

AU - Cooke, J.

N1 - © 2022 British Association of Dermatologists

PY - 2022/7/1

Y1 - 2022/7/1

N2 - A 43‐year‐old Taiwanese man presented to the emergency department with flaccid oral and genital blisters, which developed after 2 weeks of a generalized erythematous macular rash. He reported conjunctivitis and was Nikolsky positive. He had recently been started on lamotrigine. His sister also had a similar problem the previous year with an antiepileptic drug. Toxic epidermal necrolysis (TEN) is suspected. Skin biopsy showed the following features: paucicellular subepidermal blister cavity, partial and full‐thickness necrosis of the overlying epidermis, normal surface orthokeratin and a mild perivascular chronic inflammatory infiltrate.

AB - A 43‐year‐old Taiwanese man presented to the emergency department with flaccid oral and genital blisters, which developed after 2 weeks of a generalized erythematous macular rash. He reported conjunctivitis and was Nikolsky positive. He had recently been started on lamotrigine. His sister also had a similar problem the previous year with an antiepileptic drug. Toxic epidermal necrolysis (TEN) is suspected. Skin biopsy showed the following features: paucicellular subepidermal blister cavity, partial and full‐thickness necrosis of the overlying epidermis, normal surface orthokeratin and a mild perivascular chronic inflammatory infiltrate.

U2 - 10.1111/ced.14793

DO - 10.1111/ced.14793

M3 - Article

SN - 0307-6938

VL - 47

SP - 1386

EP - 1387

JO - Clinical and Experimental Dermatology

JF - Clinical and Experimental Dermatology

IS - 7

ER -