Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants

Carsten Flohr (Lead / Corresponding author), Michael Perkin, Kirsty Logan, Tom Marrs, Suzana Radulovic, Linda E Campbell, Stephanie F Maccallum, W H Irwin McLean, Gideon Lack

    Research output: Contribution to journalArticlepeer-review

    120 Citations (Scopus)

    Abstract

    Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL). We investigated whether FLG mutation inheritance, skin barrier impairment, and AD also predispose to allergic sensitization to foods. Six hundred and nineteen exclusively breastfed infants were recruited at 3 months of age and examined for AD and disease severity (SCORing Atopic Dermatitis (SCORAD)), and screened for the common FLG mutations. TEWL was measured on unaffected forearm skin. In addition, skin prick testing was performed to six study foods (cow's milk, egg, cod, wheat, sesame, and peanut). Children with AD were significantly more likely to be sensitized (adjusted odds ratio (OR)=6.18, 95% confidence interval (CI): 2.94-12.98, P
    Original languageEnglish
    Pages (from-to)345-350
    Number of pages6
    JournalJournal of Investigative Dermatology
    Volume134
    Issue number2
    DOIs
    Publication statusPublished - Feb 2014

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