Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants

Carsten Flohr; Michael Perkin; Kirsty Logan; Tom Marrs; Suzana Radulovic; Linda E Campbell; Stephanie F Maccallum; W H Irwin McLean; Gideon Lack

doi:10.1038/jid.2013.298

Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants

Carsten Flohr (Lead / Corresponding author), Michael Perkin, Kirsty Logan, Tom Marrs, Suzana Radulovic, Linda E Campbell, Stephanie F Maccallum, W H Irwin McLean, Gideon Lack

Research output: Contribution to journal › Article › peer-review

149 Citations (Scopus)

Abstract

Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL). We investigated whether FLG mutation inheritance, skin barrier impairment, and AD also predispose to allergic sensitization to foods. Six hundred and nineteen exclusively breastfed infants were recruited at 3 months of age and examined for AD and disease severity (SCORing Atopic Dermatitis (SCORAD)), and screened for the common FLG mutations. TEWL was measured on unaffected forearm skin. In addition, skin prick testing was performed to six study foods (cow's milk, egg, cod, wheat, sesame, and peanut). Children with AD were significantly more likely to be sensitized (adjusted odds ratio (OR)=6.18, 95% confidence interval (CI): 2.94-12.98, P

Original language	English
Pages (from-to)	345-350
Number of pages	6
Journal	Journal of Investigative Dermatology
Volume	134
Issue number	2
DOIs	https://doi.org/10.1038/jid.2013.298
Publication status	Published - Feb 2014

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10.1038/jid.2013.298

Dermatology and Genetic Medicine (Strategic Grant) (Joint with Kings College London)
Barton, G., Campbell, P., Hickerson, R., Leigh, I., McLean, I. & Wyatt, P.
Wellcome Trust
1/08/12 → 30/04/19
Project: Research
Human and Mouse Genetics Studies of Filaggrin-Related Proteins in Eczema and Allergy (Joint with Trinity College Dublin)
Barton, G. & McLean, I.
Wellcome Trust
1/10/10 → 28/02/14
Project: Research
Aref#d: 22163. The Establishment of a Large Case Collection of Childhood Atopic Dermatitis: A Resource for Gemetoc Research (Joint with Trinity College Dublin)
McLean, I.
Wellcome Trust
1/03/10 → 28/02/14
Project: Research

Cite this

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title = "Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants",

abstract = "Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL). We investigated whether FLG mutation inheritance, skin barrier impairment, and AD also predispose to allergic sensitization to foods. Six hundred and nineteen exclusively breastfed infants were recruited at 3 months of age and examined for AD and disease severity (SCORing Atopic Dermatitis (SCORAD)), and screened for the common FLG mutations. TEWL was measured on unaffected forearm skin. In addition, skin prick testing was performed to six study foods (cow's milk, egg, cod, wheat, sesame, and peanut). Children with AD were significantly more likely to be sensitized (adjusted odds ratio (OR)=6.18, 95% confidence interval (CI): 2.94-12.98, P",

author = "Carsten Flohr and Michael Perkin and Kirsty Logan and Tom Marrs and Suzana Radulovic and Campbell, {Linda E} and Maccallum, {Stephanie F} and McLean, {W H Irwin} and Gideon Lack",

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AU - Flohr, Carsten

AU - Perkin, Michael

AU - Logan, Kirsty

AU - Marrs, Tom

AU - Radulovic, Suzana

AU - Campbell, Linda E

AU - Maccallum, Stephanie F

AU - McLean, W H Irwin

AU - Lack, Gideon

PY - 2014/2

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N2 - Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL). We investigated whether FLG mutation inheritance, skin barrier impairment, and AD also predispose to allergic sensitization to foods. Six hundred and nineteen exclusively breastfed infants were recruited at 3 months of age and examined for AD and disease severity (SCORing Atopic Dermatitis (SCORAD)), and screened for the common FLG mutations. TEWL was measured on unaffected forearm skin. In addition, skin prick testing was performed to six study foods (cow's milk, egg, cod, wheat, sesame, and peanut). Children with AD were significantly more likely to be sensitized (adjusted odds ratio (OR)=6.18, 95% confidence interval (CI): 2.94-12.98, P

AB - Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL). We investigated whether FLG mutation inheritance, skin barrier impairment, and AD also predispose to allergic sensitization to foods. Six hundred and nineteen exclusively breastfed infants were recruited at 3 months of age and examined for AD and disease severity (SCORing Atopic Dermatitis (SCORAD)), and screened for the common FLG mutations. TEWL was measured on unaffected forearm skin. In addition, skin prick testing was performed to six study foods (cow's milk, egg, cod, wheat, sesame, and peanut). Children with AD were significantly more likely to be sensitized (adjusted odds ratio (OR)=6.18, 95% confidence interval (CI): 2.94-12.98, P

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DO - 10.1038/jid.2013.298

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Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants

Abstract

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Projects

Dermatology and Genetic Medicine (Strategic Grant) (Joint with Kings College London)

Human and Mouse Genetics Studies of Filaggrin-Related Proteins in Eczema and Allergy (Joint with Trinity College Dublin)

Aref#d: 22163. The Establishment of a Large Case Collection of Childhood Atopic Dermatitis: A Resource for Gemetoc Research (Joint with Trinity College Dublin)

Cite this