The effect of atrial natriuretic factor (ANF) 99-126 3 or 10 pmol/kg/min on increase in plasma renin activity (PRA) stimulated by a 30-min infusion of prostaglandin E2 (PGE2) 80 ng/kg/min was studied in healthy salt-replete male volunteers. PGE2 increased PRA to approximately 230% of basal levels (p less than 0.001). Concomitant infusion of ANF 3 pmol/kg/min significantly attenuated this rise in PRA to approximately 130% of baseline values (p = 0.02, n = 10). A quantitatively similar effect was observed with ANF 10 pmol/kg/min (n = 5). We suggest, in light of previous findings, that this inhibitory effect of ANF probably represents a nonspecific action rather than a specific effect of ANF on PGE2-mediated increases in PRA.
|Number of pages||5|
|Journal||Journal of Cardiovascular Pharmacology|
|Publication status||Published - 1989|
McMurray, J., McFarlane, L., Coutie, W., Balfour, D., & Struthers, A. (1989). Atrial natriuretic factor attenuates prostaglandin E2-stimulated plasma renin activity in humans. Journal of Cardiovascular Pharmacology, 14(2), 326-30. http://journals.lww.com/cardiovascularpharm/Abstract/1989/08000/Atrial_Natriuretic_Factor_Attenuates_Prostaglandin.21.aspx