Atrial natriuretic factor inhibits ACTH stimulated aldosterone, but not cortisol, secretion in man

J. McMurray, W. J. R. Coutie, L. McFarlane, A. D. Struthers

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    The effects of human ANF 99-126 on the aldosterone and cortisol responses to ACTH infusion were studied in 8 normal volunteers. ACTH infusion caused a significant rise in aldosterone and cortisol on each study day. On the day that ANF was concomitantly infused the aldosterone, but not the cortisol, response to ACTH was significantly attenuated. These results show that a pharmacological dose of ANF selectively inhibits ACTH mediated mineralocorticoid as opposed to glucocorticoid release in man. These results support in vitro and in vivo findings from animal experiments. These findings also compliment previous studies showing that ANF inhibits ANG II stimulated aldosterone release in normal subjects.
    Original languageEnglish
    Pages (from-to)409-412
    Number of pages4
    JournalEuropean Journal of Clinical Pharmacology
    Volume35
    Issue number4
    DOIs
    Publication statusPublished - 1 Jul 1988

    Fingerprint

    Atrial Natriuretic Factor
    Aldosterone
    Adrenocorticotropic Hormone
    Hydrocortisone
    Mineralocorticoids
    Glucocorticoids
    Healthy Volunteers
    Pharmacology

    Keywords

    • Atrial natriuretic factor
    • ANF
    • Adrenocorticotrophic hormone
    • ACTH
    • Aldosterone secretion
    • Cortisol
    • Angiotensin II

    Cite this

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    title = "Atrial natriuretic factor inhibits ACTH stimulated aldosterone, but not cortisol, secretion in man",
    abstract = "The effects of human ANF 99-126 on the aldosterone and cortisol responses to ACTH infusion were studied in 8 normal volunteers. ACTH infusion caused a significant rise in aldosterone and cortisol on each study day. On the day that ANF was concomitantly infused the aldosterone, but not the cortisol, response to ACTH was significantly attenuated. These results show that a pharmacological dose of ANF selectively inhibits ACTH mediated mineralocorticoid as opposed to glucocorticoid release in man. These results support in vitro and in vivo findings from animal experiments. These findings also compliment previous studies showing that ANF inhibits ANG II stimulated aldosterone release in normal subjects.",
    keywords = "Atrial natriuretic factor , ANF, Adrenocorticotrophic hormone, ACTH, Aldosterone secretion, Cortisol, Angiotensin II",
    author = "J. McMurray and Coutie, {W. J. R.} and L. McFarlane and Struthers, {A. D.}",
    year = "1988",
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    doi = "10.1007/BF00561373",
    language = "English",
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    Atrial natriuretic factor inhibits ACTH stimulated aldosterone, but not cortisol, secretion in man. / McMurray, J.; Coutie, W. J. R.; McFarlane, L.; Struthers, A. D.

    In: European Journal of Clinical Pharmacology, Vol. 35, No. 4, 01.07.1988, p. 409-412.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Atrial natriuretic factor inhibits ACTH stimulated aldosterone, but not cortisol, secretion in man

    AU - McMurray, J.

    AU - Coutie, W. J. R.

    AU - McFarlane, L.

    AU - Struthers, A. D.

    PY - 1988/7/1

    Y1 - 1988/7/1

    N2 - The effects of human ANF 99-126 on the aldosterone and cortisol responses to ACTH infusion were studied in 8 normal volunteers. ACTH infusion caused a significant rise in aldosterone and cortisol on each study day. On the day that ANF was concomitantly infused the aldosterone, but not the cortisol, response to ACTH was significantly attenuated. These results show that a pharmacological dose of ANF selectively inhibits ACTH mediated mineralocorticoid as opposed to glucocorticoid release in man. These results support in vitro and in vivo findings from animal experiments. These findings also compliment previous studies showing that ANF inhibits ANG II stimulated aldosterone release in normal subjects.

    AB - The effects of human ANF 99-126 on the aldosterone and cortisol responses to ACTH infusion were studied in 8 normal volunteers. ACTH infusion caused a significant rise in aldosterone and cortisol on each study day. On the day that ANF was concomitantly infused the aldosterone, but not the cortisol, response to ACTH was significantly attenuated. These results show that a pharmacological dose of ANF selectively inhibits ACTH mediated mineralocorticoid as opposed to glucocorticoid release in man. These results support in vitro and in vivo findings from animal experiments. These findings also compliment previous studies showing that ANF inhibits ANG II stimulated aldosterone release in normal subjects.

    KW - Atrial natriuretic factor

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    KW - Adrenocorticotrophic hormone

    KW - ACTH

    KW - Aldosterone secretion

    KW - Cortisol

    KW - Angiotensin II

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