Atrial natriuretic factor inhibits isoproterenol- and furosemide-stimulated renin release in humans

J. J. McMurray, A. D. Struthers

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    The effects of atrial natriuretic factor (0.025 microgram/kg/min) on isoproterenol-(0.02 microgram/kg/min) and furosemide-(5 mg i.v. bolus) stimulated renin release were studied in seven salt-replete healthy volunteers. Isoproterenol or furosemide were given against a background infusion of 5% D-glucose (placebo day) or atrial natriuretic factor (experimental day). Atrial natriuretic factor abolished the rise in plasma renin activity caused by isoproterenol (p = 0.003) and significantly (p = 0.048) attenuated the rise in plasma renin activity after a bolus injection of furosemide. These results show that a pharmacological dose of atrial natriuretic factor inhibits stimulated renin release in humans. This attenuation is apparent with two heterogenous stimuli, which suggests a nonspecific effect.
    Original languageEnglish
    Pages (from-to)9-14
    Number of pages6
    JournalHypertension
    Volume13
    Issue number1
    DOIs
    Publication statusPublished - Jan 1989

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