Atrial natriuretic peptide: an endogenous factor enhancing sodium excretion in man

John Anderson, Allan Struthers, Nic Christofides, Stephen Bloom

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    Abstract

    For many years experimental evidence has suggested the existence of a circulating factor able to enhance sodium excretion. Very recently peptides with natriuretic activity in experimental animals have been isolated from mammalian and human cardiac tissue. In order to determine whether this natriuretic activity has relevance to man we have studied the effects of an infusion of alpha-human atrial natriuretic peptide (alpha-h-ANP) in normal subjects. Sodium excretion trebled (P = less than 0.005) during the infusion of a calculated dose of 15 pmol of alpha-h-ANP min-1 kg-1 and there was an accompanying diuresis; radioimmunoassay of plasma alpha-h-ANP during the natriuresis indicated a mean peak incremental concentration of 203 +/- 78 (SEM) pmol/l. The infusion of a calculated dose of 1.5 pmol min-1 kg-1 did not affect sodium excretion. There were no haemodynamic changes and no side effects were noted.
    Original languageEnglish
    Pages (from-to)327-331
    Number of pages5
    JournalClinical Science
    Volume70
    Issue number4
    DOIs
    Publication statusPublished - Apr 1986

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    Keywords

    • Atrial natriuretic peptide
    • Natriuretic factor
    • Salt excretition
    • Sodium
    • Water excretion

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