Atrial natriuretic peptide inhibits the aldosterone response to angiotensin II in man

J. V. Anderson, A. D. Struthers, N. N. Payne, J. D. H. Slater, S. R. Bloom

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    Abstract

    We have investigated the interaction between the recently discovered natriuretic factor alpha human atrial natriuretic peptide (alpha h-ANP) and the renin-angiotensin-aldosterone system in man. Angiotensin II infused with placebo produced a significant rise of plasma aldosterone concentration (mean +/- SEM increment 352 +/- 23 pmol/l, n = 7, P less than 0.001). The infusion of alpha h-ANP together with angiotensin II largely abolished the aldosterone response (P less than 0.001). Diastolic blood pressure rose in response to the infusion of angiotensin II with placebo (mean increment 21.0 +/- 0.9 mmHg, P less than 0.001). Systolic blood pressure increased to a lesser degree (mean increment 12.5 +/- 0.7 mmHg, P less than 0.001). The infusion of alpha h-ANP together with angiotensin II significantly blunted the diastolic pressor response (P less than 0.01). This ability of alpha h-ANP to blunt the pressor effect of angiotensin II may be important in the control of systemic blood pressure. The inhibition of angiotensin II-stimulated aldosterone release demonstrates that alpha h-ANP may not only be a circulating natriuretic factor in its own right but that it may also act as a modulator of a related endocrine system.
    Original languageEnglish
    Pages (from-to)507-512
    Number of pages6
    JournalClinical Science
    Volume70
    Issue number5
    DOIs
    Publication statusPublished - May 1986

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    Keywords

    • Aldosterone
    • Angiotensin II
    • Atrial natriuretic peptide
    • Natriuresis
    • Natriuretic factor
    • Renin-angiotensin system

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