ATRX: put me on repeat

Iestyn Whitehouse, Tom Owen-Hughes

    Research output: Contribution to journalEditorial

    11 Citations (Scopus)

    Abstract

    Mutations in the chromatin-remodeling protein ATRX cause alpha thalassaemia and mental retardation, but the severity of the disorder is independent of the specific mutation. In this issue of Cell, Law et al. (2010) demonstrate that ATRX alters gene expression by binding to G-rich tandem repeats, and the degree of transcriptional silencing caused by ATRX mutations correlates with the number of repeats.

    Original languageEnglish
    Pages (from-to)335-336
    Number of pages2
    JournalCell
    Volume143
    Issue number3
    DOIs
    Publication statusPublished - 29 Oct 2010

    Keywords

    • HISTONE CHAPERONE
    • H3.3
    • DAXX
    • MUTATIONS
    • REGIONS

    Cite this