ATRX

put me on repeat

Iestyn Whitehouse, Tom Owen-Hughes

    Research output: Contribution to journalEditorial

    10 Citations (Scopus)

    Abstract

    Mutations in the chromatin-remodeling protein ATRX cause alpha thalassaemia and mental retardation, but the severity of the disorder is independent of the specific mutation. In this issue of Cell, Law et al. (2010) demonstrate that ATRX alters gene expression by binding to G-rich tandem repeats, and the degree of transcriptional silencing caused by ATRX mutations correlates with the number of repeats.

    Original languageEnglish
    Pages (from-to)335-336
    Number of pages2
    JournalCell
    Volume143
    Issue number3
    DOIs
    Publication statusPublished - 29 Oct 2010

    Keywords

    • HISTONE CHAPERONE
    • H3.3
    • DAXX
    • MUTATIONS
    • REGIONS

    Cite this

    Whitehouse, Iestyn ; Owen-Hughes, Tom. / ATRX : put me on repeat. In: Cell. 2010 ; Vol. 143, No. 3. pp. 335-336.
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    abstract = "Mutations in the chromatin-remodeling protein ATRX cause alpha thalassaemia and mental retardation, but the severity of the disorder is independent of the specific mutation. In this issue of Cell, Law et al. (2010) demonstrate that ATRX alters gene expression by binding to G-rich tandem repeats, and the degree of transcriptional silencing caused by ATRX mutations correlates with the number of repeats.",
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    author = "Iestyn Whitehouse and Tom Owen-Hughes",
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    language = "English",
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    ATRX : put me on repeat. / Whitehouse, Iestyn; Owen-Hughes, Tom.

    In: Cell, Vol. 143, No. 3, 29.10.2010, p. 335-336.

    Research output: Contribution to journalEditorial

    TY - JOUR

    T1 - ATRX

    T2 - put me on repeat

    AU - Whitehouse, Iestyn

    AU - Owen-Hughes, Tom

    PY - 2010/10/29

    Y1 - 2010/10/29

    N2 - Mutations in the chromatin-remodeling protein ATRX cause alpha thalassaemia and mental retardation, but the severity of the disorder is independent of the specific mutation. In this issue of Cell, Law et al. (2010) demonstrate that ATRX alters gene expression by binding to G-rich tandem repeats, and the degree of transcriptional silencing caused by ATRX mutations correlates with the number of repeats.

    AB - Mutations in the chromatin-remodeling protein ATRX cause alpha thalassaemia and mental retardation, but the severity of the disorder is independent of the specific mutation. In this issue of Cell, Law et al. (2010) demonstrate that ATRX alters gene expression by binding to G-rich tandem repeats, and the degree of transcriptional silencing caused by ATRX mutations correlates with the number of repeats.

    KW - HISTONE CHAPERONE

    KW - H3.3

    KW - DAXX

    KW - MUTATIONS

    KW - REGIONS

    U2 - 10.1016/j.cell.2010.10.021

    DO - 10.1016/j.cell.2010.10.021

    M3 - Editorial

    VL - 143

    SP - 335

    EP - 336

    JO - Cell

    JF - Cell

    SN - 0092-8674

    IS - 3

    ER -