AT2 receptor stimulation may halt progression of pheochromocytoma

Morris J. Brown (Lead / Corresponding author), Isla S. Mackenzie, Michael J. Ashby, Kottekkattu K. Balan, Derek S. Appleton

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)


    Two patients with pheochromocytoma are described in whom treatment with a high dose of an angiotensin receptor blocker was associated with cessation of tumor growth as assessed by serial CT scanning and plasma norepinephrine estimation. If the association with drug treatment is causal, the mechanism may be through stimulation of the AT2 receptor consequent upon the elevation of plasma angiotensin II levels induced by AT1 receptor blockade. Similar observations in further patients should lead to a placebo-controlled study in patients with malignant or familial pheochromocytoma, or other tumors found to express the AT2 receptor.

    Original languageEnglish
    Pages (from-to)436-443
    Number of pages8
    JournalAnnals of the New York Academy of Sciences
    Issue number1
    Publication statusPublished - Aug 2006


    • Angiotensin receptor blocker
    • F-DOPA scan
    • Malignant
    • Pheochromocytoma
    • Treatment

    ASJC Scopus subject areas

    • General Neuroscience
    • General Biochemistry,Genetics and Molecular Biology
    • History and Philosophy of Science


    Dive into the research topics of 'AT2 receptor stimulation may halt progression of pheochromocytoma'. Together they form a unique fingerprint.

    Cite this