AT2 receptor stimulation may halt progression of pheochromocytoma

Morris J. Brown; Isla S. Mackenzie; Michael J. Ashby; Kottekkattu K. Balan; Derek S. Appleton

doi:10.1196/annals.1353.047

AT₂ receptor stimulation may halt progression of pheochromocytoma

Morris J. Brown (Lead / Corresponding author), Isla S. Mackenzie, Michael J. Ashby, Kottekkattu K. Balan, Derek S. Appleton

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Two patients with pheochromocytoma are described in whom treatment with a high dose of an angiotensin receptor blocker was associated with cessation of tumor growth as assessed by serial CT scanning and plasma norepinephrine estimation. If the association with drug treatment is causal, the mechanism may be through stimulation of the AT₂ receptor consequent upon the elevation of plasma angiotensin II levels induced by AT¹ receptor blockade. Similar observations in further patients should lead to a placebo-controlled study in patients with malignant or familial pheochromocytoma, or other tumors found to express the AT₂ receptor.

Original language	English
Pages (from-to)	436-443
Number of pages	8
Journal	Annals of the New York Academy of Sciences
Volume	1073
Issue number	1
DOIs	https://doi.org/10.1196/annals.1353.047
Publication status	Published - Aug 2006

Keywords

Angiotensin receptor blocker
F-DOPA scan
Malignant
Pheochromocytoma
Treatment

ASJC Scopus subject areas

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

Access to Document

10.1196/annals.1353.047Licence: Other

Cite this

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AU - Appleton, Derek S.

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