TY - JOUR
T1 - Author Correction
T2 - New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (Nature Genetics, (2019), 10.1038/s41588-018-0321-7)
AU - Shrine, Nick
AU - Guyatt, Anna L
AU - Erzurumluoglu, A Mesut
AU - Jackson, Victoria E.
AU - Hobbs, Brian D
AU - Melbourne, Carl A
AU - Batini, Chiara
AU - Fawcett, Katherine A
AU - Song, Kijoung
AU - Sakornsakolpat, Phuwanat
AU - Li, Xingnan
AU - Boxall, Ruth
AU - Reeve, Nicola F
AU - Obeidat, Ma'en
AU - Zhao, Jing Hua
AU - Wielscher, Matthias
AU - Understanding Society Scientific Group
AU - Weiss, Stefan
AU - Kentistou, Katherine A
AU - Cook, James P
AU - Sun, Benjamin B
AU - Zhou, Jian
AU - Hui, Jennie
AU - Karrasch, Stefan
AU - Imboden, Medea
AU - Harris, Sarah E
AU - Marten, Jonathan
AU - Enroth, Stefan
AU - Kerr, Shona M
AU - Surakka, Ida
AU - Vitart, Veronique
AU - Lehtimäki, Terho
AU - Allen, Richard J
AU - Bakke, Per S
AU - Beaty, Terri H
AU - Bleecker, Eugene R
AU - Bossé, Yohan
AU - Brandsma, Corry-Anke
AU - Chen, Zhengming
AU - Crapo, James D
AU - Danesh, John
AU - DeMeo, Dawn L
AU - Dudbridge, Frank
AU - Ewert, Ralf
AU - Gieger, Christian
AU - Gulsvik, Amund
AU - Hansell, Anna L
AU - Hao, Ke
AU - Hoffman, Joshua D
AU - Hokanson, John E
AU - Homuth, Georg
AU - Joshi, Peter K.
AU - Joubert, Philippe
AU - Langenberg, Claudia
AU - Li, Xuan
AU - Li, Liming
AU - Lin, Kuang
AU - Lind, Lars
AU - Locantore, Nicholas
AU - Luan, Jian'an
AU - Mahajan, Anubha
AU - Maranville, Joseph C.
AU - Murray, Alison D.
AU - Nickle, David C.
AU - Packer, Richard
AU - Parker, Margaret M.
AU - Paynton, Megan L.
AU - Porteous, David J.
AU - Prokopenko, Dmitry
AU - Qiao, Dandi
AU - Rawal, Rajesh
AU - Runz, Heiko
AU - Sayers, Ian
AU - Smith, Blair H
AU - Sin, Don D.
AU - Artigas, María Soler
AU - Sparrow, David
AU - Tal-Singer, Ruth
AU - Timmers, Paul R.H.J.
AU - Van den Berge, Maarten
AU - Whittaker, John C.
AU - Woodruff, Prescott G.
AU - Yerges-Armstrong, Laura M.
AU - Troyanskaya, Olga G.
AU - Raitakari, Olli T.
AU - Kähönen, Mika
AU - Polasek, Ozren
AU - Gyllensten, Ulf B.
AU - Rudan, Igor
AU - Deary, Ian J.
AU - Probst-Hensch, Nicole M.
AU - Schulz, Holger
AU - James, Alan L.
AU - Wilson, James F.
AU - Stubbe, Beate
AU - Zeggini, Eleftheria
AU - Järvelin, Marjo-Riitta
AU - Wareham, Nick
AU - Silverman, Edwin K.
AU - Hayward, Caroline
AU - Morris, Andrew P.
AU - Butterworth, Adam S.
AU - Scott, Robert A.
AU - Walters, Robin G
AU - Meyers, Deborah A.
AU - Cho, Michael H.
AU - Strachan, David P.
AU - Hall, Ian P.
AU - Tobin, Martin D.
AU - Wain, Louise V.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.
PY - 2024/5
Y1 - 2024/5
N2 - Correction to: Nature Geneticshttps://doi.org/10.1038/s41588-018-0321-7, published online 25 February 2019. In the version of the article initially published, unconsented individuals were erroneously included in SPIROMICS consortium results. The analysis has now been repeated with the unconsented individuals removed. The change in the results does not affect the conclusions in the paper. The corrections required to the paper are as follows: In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. The correction is due to 26 unconsented SPIROMICS samples being originally included in the analysis. The analyses that previously included these samples have been rerun with data from these 26 samples removed. Supplementary Information accompanies the online version of this amendment and includes: Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data. Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data.
AB - Correction to: Nature Geneticshttps://doi.org/10.1038/s41588-018-0321-7, published online 25 February 2019. In the version of the article initially published, unconsented individuals were erroneously included in SPIROMICS consortium results. The analysis has now been repeated with the unconsented individuals removed. The change in the results does not affect the conclusions in the paper. The corrections required to the paper are as follows: In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. In the third paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “(n = 6,979 cases and 3,915 controls)”, should be “(n = 6,964 cases and 3,904 controls)” and “P = 2.87 × 10–75” should be “P = 2.21 × 10–75”. In the fourth paragraph of the “Association with FEV1/FVC and COPD in multiple ancestries” section: “4.73 (95% CI: [3.79, 5.90]), P = 3.00 × 10−43”, should be “4.71 (95% CI: [3.77, 5.87]), P = 7.24 × 10−43”. In the Fig. 3b table, the SPIROMICS row: “1.54, 1.38, 1.72, 4.47 × 10–14, 988, 537”, should be “1.55, 1.39, 1.74, 6.80 × 10–14, 973, 526”; and the Meta-analysis row: “1.55, 1.48, 1.62, 1.48 × 10–75, 6,979, 3,915”, should be “1.55, 1.48, 1.62, 2.21 × 10–75, 6,964, 3,904”. In the final paragraph of the Discussion: “The 279-variant GRS we constructed was associated with a 4.73-fold increased relative risk…”, should be “The 279-variant GRS we constructed was associated with a 4.71-fold increased relative risk…” In the fifth paragraph of the “Effect of genetic risk score on COPD susceptibility in multiple ancestries” section in the Methods: “SPIROMICS (988 cases, 537 controls)”, should be “SPIROMICS (973 cases, 526 controls)”. The correction is due to 26 unconsented SPIROMICS samples being originally included in the analysis. The analyses that previously included these samples have been rerun with data from these 26 samples removed. Supplementary Information accompanies the online version of this amendment and includes: Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data. Updated Supplementary Text and Figures wherein we have changed: On page 23 (description of SPIROMICS cohort) the number of COPD cases has been changed from 988 to 973 and controls from 537 to 526. Supplementary Figure 9 – the forest plots have been updated for the new results for association with 279 variants after reanalysis of SPIROMICS. Supplementary Table 20 – the demographics for SPIROMICS have been updated. Supplementary Table 21 – the results rows for the SPIROMICS and “Meta-analysis of 5 European-ancestry study groups” have been updated. Supplementary Table 22 – The “Meta-analysis of 5 European cohorts” columns have been updated after SPIROMICS reanalysis. Updated Supplementary Tables wherein we have changed: Supplementary Table 29 – columns X–Z (“Meta-analysis of 5 external European-ancestry COPD cohorts (Cases = 6,964; Controls = 3,904)”) after reanalysis of SPIROMICS data.
UR - http://www.scopus.com/inward/record.url?scp=85192394658&partnerID=8YFLogxK
U2 - 10.1038/s41588-024-01752-4
DO - 10.1038/s41588-024-01752-4
M3 - Article
C2 - 38641645
SN - 1061-4036
VL - 56
SP - 1032
EP - 1033
JO - Nature Genetics
JF - Nature Genetics
IS - 5
ER -