Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis

G C M Smith, C R Wolf, J G Kenna, D J Harrison, D Tew

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    47 Citations (Scopus)

    Abstract

    Halothane hepatitis can be life-threatening, and this severe adverse reaction may arise via an immune process. We have detected autoantibodies to purified human liver microsomal carboxylesterase in sera of 17 out of 20 patients with halothane hepatitis (85%) but not in 9 halothane-exposed controls and in only 2 (at low levels) of 33 patients with liver disease due to other causes. Immunohistochemical studies localised the carboxylesterase predominantly to the centrilobular region of liver sections, which is consistent with the area affected by halothane hepatitis. Human hepatic microsomal carboxylesterase is a target antigen in halothane hepatitis, and an immune response to this protein may be involved in the liver damage observed.
    Original languageEnglish
    Pages (from-to)963-4
    Number of pages2
    JournalLancet
    Volume342
    Issue number8877
    DOIs
    Publication statusPublished - 1993

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