Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia

S. MacCallum, M. Groves, D. Brass, J. Cunningham, M. Sales, K. Gelly, S. Tauro

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    Abstract

    Autoimmune haemolysis or thrombocytopenia can complicate purine nucleoside monotherapy for chronic lymphocytic leukaemia (CLL), but Evans syndrome is rare. This is a report of the occurrence of pancytopenia secondary to a unique combination of red cell aplasia with autoimmune thrombocytopenia and neutropenia in a patient with CLL following treatment with fludarabine and cyclophosphamide. This case is unusual for the simultaneous targeting of three haemopoietic lineages by immune dysfunction following fludarabine and cyclophosphamide, which is a treatment regimen believed to reduce autoimmune haematological toxicity in CLL.

    Original languageEnglish
    Pages (from-to)468-470
    Number of pages3
    JournalJournal of Clinical Pathology
    Volume62
    Issue number5
    DOIs
    Publication statusPublished - 2009

    Keywords

    • RED-CELL APLASIA
    • FLUDARABINE
    • CYCLOPHOSPHAMIDE
    • CLL
    • RITUXIMAB

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