Abstract
Autoimmune haemolysis or thrombocytopenia can complicate purine nucleoside monotherapy for chronic lymphocytic leukaemia (CLL), but Evans syndrome is rare. This is a report of the occurrence of pancytopenia secondary to a unique combination of red cell aplasia with autoimmune thrombocytopenia and neutropenia in a patient with CLL following treatment with fludarabine and cyclophosphamide. This case is unusual for the simultaneous targeting of three haemopoietic lineages by immune dysfunction following fludarabine and cyclophosphamide, which is a treatment regimen believed to reduce autoimmune haematological toxicity in CLL.
Original language | English |
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Pages (from-to) | 468-470 |
Number of pages | 3 |
Journal | Journal of Clinical Pathology |
Volume | 62 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2009 |
Keywords
- RED-CELL APLASIA
- FLUDARABINE
- CYCLOPHOSPHAMIDE
- CLL
- RITUXIMAB