Autoinhibition and adapter function of Syk

Yogesh Kulathu, Gesina Grothe, Michael Reth

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)


Summary: Development, survival, and activation of B lymphocytes are controlled by signals emanating from the B-cell antigen receptor (BCR). The BCR has an autonomous signaling function also known as tonic signaling that allows for long-term survival of B cells in the immune system. Upon binding of antigen to the BCR, the tonic signal is amplified and diversified, leading to alteration in gene expression and B-cell activation. The spleen tyrosine kinase (Syk) intimately cooperates with the signaling subunits of the BCR and plays a central role in the amplification and diversification of BCR signals. In this review, we discuss the molecular mechanisms by which Syk activity is inhibited and activated at the BCR. Importantly, Syk acts not only as a kinase that phosphorylates downstream substrates but also as an adapter that can bind to a diverse set of signaling proteins. Depending on its interactions and localization, Syk can signal opposing cell fate decisions such as proliferation or differentiation of B cells.

Original languageEnglish
Pages (from-to)286-299
Number of pages14
JournalImmunological Reviews
Issue number1
Publication statusPublished - Nov 2009


  • Adapters
  • Autoinhibition
  • Immunoreceptor tyrosine-based activation motif
  • Lymphocyte signaling
  • Pre-B-cell receptor signaling
  • Protein kinases

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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