Automated detection of neutropenia using non‐invasive video microscopy of superficial capillaries

Alberto Pablo-Trinidad, Ian Butterworth, María J. Ledesma‐Carbayo, Tom Vettenburg, Álvaro Sánchez‐Ferro, Luis Soenksen, Nicholas J. Durr, Arrate Muñoz Barrutia, Carolina Cerrato, Karem Humala, Marta Fabra Urdiol, Candice Del Rio, Betsy Valles, Yi‐Bin Chen, Ephraim P. Hochberg, Carlos Castro‐González, Aurélien Bourquard (Lead / Corresponding author)

Research output: Contribution to journalLetter

Abstract

Cancer patients undergoing cytotoxic chemotherapy are at elevated risk of developing serious infections. The risk of developing these infections increases when white blood cell (WBC) count, particularly the absolute neutrophil counts (ANC), are reduced. This reduction in neutrophil counts, the most abundant white-blood-cell subtype, is referred to as neutropenia, with these infection episodes termed febrile neutropenia (FN). Patients have a high risk of developing FN during sustained severe neutropenia (ANC<500/μL), which is a common side effect of cytotoxic chemotherapies. FN occurs frequently, currently in approximately one in six of all chemotherapy patients, and it is associated with a high rate of mortality, where 11% of patients die after one or several hospitalizations. In the US alone, the associated cost due to such hospitalizations accounts for $2.7B dollars annually, contributing to up to 40% of the total cost of cancer treatments.
Original languageEnglish
Pages (from-to)E219-E222
Number of pages6
JournalAmerican Journal of Hematology
Volume94
Issue number8
Early online date23 May 2019
DOIs
Publication statusPublished - 1 Aug 2019

Fingerprint

Video Microscopy
Neutropenia
Febrile Neutropenia
Neutrophils
Drug Therapy
Hospitalization
Infection
Leukocyte Count
Health Care Costs
Neoplasms
Leukocytes
Costs and Cost Analysis
Mortality

Cite this

Pablo-Trinidad, A., Butterworth, I., Ledesma‐Carbayo, M. J., Vettenburg, T., Sánchez‐Ferro, Á., Soenksen, L., ... Bourquard, A. (2019). Automated detection of neutropenia using non‐invasive video microscopy of superficial capillaries. American Journal of Hematology, 94(8), E219-E222. https://doi.org/10.1002/ajh.25516
Pablo-Trinidad, Alberto ; Butterworth, Ian ; Ledesma‐Carbayo, María J. ; Vettenburg, Tom ; Sánchez‐Ferro, Álvaro ; Soenksen, Luis ; Durr, Nicholas J. ; Muñoz Barrutia, Arrate ; Cerrato, Carolina ; Humala, Karem ; Fabra Urdiol, Marta ; Del Rio, Candice ; Valles, Betsy ; Chen, Yi‐Bin ; Hochberg, Ephraim P. ; Castro‐González, Carlos ; Bourquard, Aurélien. / Automated detection of neutropenia using non‐invasive video microscopy of superficial capillaries. In: American Journal of Hematology. 2019 ; Vol. 94, No. 8. pp. E219-E222.
@article{3da34cac2eb5481aa181507356614c15,
title = "Automated detection of neutropenia using non‐invasive video microscopy of superficial capillaries",
abstract = "Cancer patients undergoing cytotoxic chemotherapy are at elevated risk of developing serious infections. The risk of developing these infections increases when white blood cell (WBC) count, particularly the absolute neutrophil counts (ANC), are reduced. This reduction in neutrophil counts, the most abundant white-blood-cell subtype, is referred to as neutropenia, with these infection episodes termed febrile neutropenia (FN). Patients have a high risk of developing FN during sustained severe neutropenia (ANC<500/μL), which is a common side effect of cytotoxic chemotherapies. FN occurs frequently, currently in approximately one in six of all chemotherapy patients, and it is associated with a high rate of mortality, where 11{\%} of patients die after one or several hospitalizations. In the US alone, the associated cost due to such hospitalizations accounts for $2.7B dollars annually, contributing to up to 40{\%} of the total cost of cancer treatments.",
author = "Alberto Pablo-Trinidad and Ian Butterworth and Ledesma‐Carbayo, {Mar{\'i}a J.} and Tom Vettenburg and {\'A}lvaro S{\'a}nchez‐Ferro and Luis Soenksen and Durr, {Nicholas J.} and {Mu{\~n}oz Barrutia}, Arrate and Carolina Cerrato and Karem Humala and {Fabra Urdiol}, Marta and {Del Rio}, Candice and Betsy Valles and Yi‐Bin Chen and Hochberg, {Ephraim P.} and Carlos Castro‐Gonz{\'a}lez and Aur{\'e}lien Bourquard",
year = "2019",
month = "8",
day = "1",
doi = "10.1002/ajh.25516",
language = "English",
volume = "94",
pages = "E219--E222",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "Wiley",
number = "8",

}

Pablo-Trinidad, A, Butterworth, I, Ledesma‐Carbayo, MJ, Vettenburg, T, Sánchez‐Ferro, Á, Soenksen, L, Durr, NJ, Muñoz Barrutia, A, Cerrato, C, Humala, K, Fabra Urdiol, M, Del Rio, C, Valles, B, Chen, YB, Hochberg, EP, Castro‐González, C & Bourquard, A 2019, 'Automated detection of neutropenia using non‐invasive video microscopy of superficial capillaries', American Journal of Hematology, vol. 94, no. 8, pp. E219-E222. https://doi.org/10.1002/ajh.25516

Automated detection of neutropenia using non‐invasive video microscopy of superficial capillaries. / Pablo-Trinidad, Alberto; Butterworth, Ian; Ledesma‐Carbayo, María J.; Vettenburg, Tom; Sánchez‐Ferro, Álvaro; Soenksen, Luis; Durr, Nicholas J.; Muñoz Barrutia, Arrate; Cerrato, Carolina; Humala, Karem; Fabra Urdiol, Marta; Del Rio, Candice; Valles, Betsy; Chen, Yi‐Bin; Hochberg, Ephraim P.; Castro‐González, Carlos; Bourquard, Aurélien (Lead / Corresponding author).

In: American Journal of Hematology, Vol. 94, No. 8, 01.08.2019, p. E219-E222.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Automated detection of neutropenia using non‐invasive video microscopy of superficial capillaries

AU - Pablo-Trinidad, Alberto

AU - Butterworth, Ian

AU - Ledesma‐Carbayo, María J.

AU - Vettenburg, Tom

AU - Sánchez‐Ferro, Álvaro

AU - Soenksen, Luis

AU - Durr, Nicholas J.

AU - Muñoz Barrutia, Arrate

AU - Cerrato, Carolina

AU - Humala, Karem

AU - Fabra Urdiol, Marta

AU - Del Rio, Candice

AU - Valles, Betsy

AU - Chen, Yi‐Bin

AU - Hochberg, Ephraim P.

AU - Castro‐González, Carlos

AU - Bourquard, Aurélien

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Cancer patients undergoing cytotoxic chemotherapy are at elevated risk of developing serious infections. The risk of developing these infections increases when white blood cell (WBC) count, particularly the absolute neutrophil counts (ANC), are reduced. This reduction in neutrophil counts, the most abundant white-blood-cell subtype, is referred to as neutropenia, with these infection episodes termed febrile neutropenia (FN). Patients have a high risk of developing FN during sustained severe neutropenia (ANC<500/μL), which is a common side effect of cytotoxic chemotherapies. FN occurs frequently, currently in approximately one in six of all chemotherapy patients, and it is associated with a high rate of mortality, where 11% of patients die after one or several hospitalizations. In the US alone, the associated cost due to such hospitalizations accounts for $2.7B dollars annually, contributing to up to 40% of the total cost of cancer treatments.

AB - Cancer patients undergoing cytotoxic chemotherapy are at elevated risk of developing serious infections. The risk of developing these infections increases when white blood cell (WBC) count, particularly the absolute neutrophil counts (ANC), are reduced. This reduction in neutrophil counts, the most abundant white-blood-cell subtype, is referred to as neutropenia, with these infection episodes termed febrile neutropenia (FN). Patients have a high risk of developing FN during sustained severe neutropenia (ANC<500/μL), which is a common side effect of cytotoxic chemotherapies. FN occurs frequently, currently in approximately one in six of all chemotherapy patients, and it is associated with a high rate of mortality, where 11% of patients die after one or several hospitalizations. In the US alone, the associated cost due to such hospitalizations accounts for $2.7B dollars annually, contributing to up to 40% of the total cost of cancer treatments.

UR - http://www.scopus.com/inward/record.url?scp=85067409963&partnerID=8YFLogxK

UR - https://discovery.dundee.ac.uk/en/publications/3da34cac-2eb5-481a-a181-507356614c15

U2 - 10.1002/ajh.25516

DO - 10.1002/ajh.25516

M3 - Letter

VL - 94

SP - E219-E222

JO - American Journal of Hematology

JF - American Journal of Hematology

SN - 0361-8609

IS - 8

ER -

Pablo-Trinidad A, Butterworth I, Ledesma‐Carbayo MJ, Vettenburg T, Sánchez‐Ferro Á, Soenksen L et al. Automated detection of neutropenia using non‐invasive video microscopy of superficial capillaries. American Journal of Hematology. 2019 Aug 1;94(8):E219-E222. https://doi.org/10.1002/ajh.25516