Autonomic function in cirrhosis assessed by cardiovascular reflex tests and 24-hour heart-rate-variability

J. F. Dillon; J. N. Plevris; J. Nolan; D. J. Ewing; J. M. M. Neilson; I. A. D. Bouchier; P. C. Hayes

Autonomic function in cirrhosis assessed by cardiovascular reflex tests and 24-hour heart-rate-variability

J. F. Dillon
, J. N. Plevris
, J. Nolan
, D. J. Ewing
, J. M. M. Neilson
, I. A. D. Bouchier
, P. C. Hayes

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To assess the prevalence of autonomic dysfunction in cirrhosis and to observe the effect of disease severity on autonomic dysfunction. Methods: Seventy patients with cirrhosis (Child's class A, 42; Child's class B, 10; and Child's class C, 15) (45 alcoholic, 15 primary biliary cirrhosis, five chronic active hepatitis, and eight idiopathic) underwent standard cardiovascular reflex tests. In addition, in 40 patients, 24-h ECG RR variability tests were performed to detect autonomic dysfunction. Results: Forty-two of 70 (60%) patients had abnormalities of cardiovascular reflex function of varying severity, whereas 24 of 34 (70%) had 24-h RR counts with the 95% age-related tolerance. The prevalence of abnormality increased with increasing severity of Liver disease but not with different etiologies. Conclusion: Irrespective of etiology, there is a high prevalence of autonomic dysfunction in cirrhosis, and it is related to disease severity: the mechanism is unknown.

Original language	Undefined/Unknown
Pages (from-to)	1544-1547
Number of pages	4
Journal	American Journal of Gastroenterology
Volume	89
Issue number	9
Publication status	Published - 1994

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

@article{a57b4ad99ae24c4ebc89cc300bc8cf29,

title = "Autonomic function in cirrhosis assessed by cardiovascular reflex tests and 24-hour heart-rate-variability",

abstract = "Objectives: To assess the prevalence of autonomic dysfunction in cirrhosis and to observe the effect of disease severity on autonomic dysfunction. Methods: Seventy patients with cirrhosis (Child's class A, 42; Child's class B, 10; and Child's class C, 15) (45 alcoholic, 15 primary biliary cirrhosis, five chronic active hepatitis, and eight idiopathic) underwent standard cardiovascular reflex tests. In addition, in 40 patients, 24-h ECG RR variability tests were performed to detect autonomic dysfunction. Results: Forty-two of 70 (60\%) patients had abnormalities of cardiovascular reflex function of varying severity, whereas 24 of 34 (70\%) had 24-h RR counts with the 95\% age-related tolerance. The prevalence of abnormality increased with increasing severity of Liver disease but not with different etiologies. Conclusion: Irrespective of etiology, there is a high prevalence of autonomic dysfunction in cirrhosis, and it is related to disease severity: the mechanism is unknown.",

author = "Dillon, \{J. F.\} and Plevris, \{J. N.\} and J. Nolan and Ewing, \{D. J.\} and Neilson, \{J. M. M.\} and Bouchier, \{I. A. D.\} and Hayes, \{P. C.\}",

note = "Times Cited: 36",

year = "1994",

language = "Undefined/Unknown",

volume = "89",

pages = "1544--1547",

journal = "American Journal of Gastroenterology",

issn = "1572-0241",

publisher = "Wolters Kluwer Health",

number = "9",

}

TY - JOUR

T1 - Autonomic function in cirrhosis assessed by cardiovascular reflex tests and 24-hour heart-rate-variability

AU - Dillon, J. F.

AU - Plevris, J. N.

AU - Nolan, J.

AU - Ewing, D. J.

AU - Neilson, J. M. M.

AU - Bouchier, I. A. D.

AU - Hayes, P. C.

N1 - Times Cited: 36

PY - 1994

Y1 - 1994

N2 - Objectives: To assess the prevalence of autonomic dysfunction in cirrhosis and to observe the effect of disease severity on autonomic dysfunction. Methods: Seventy patients with cirrhosis (Child's class A, 42; Child's class B, 10; and Child's class C, 15) (45 alcoholic, 15 primary biliary cirrhosis, five chronic active hepatitis, and eight idiopathic) underwent standard cardiovascular reflex tests. In addition, in 40 patients, 24-h ECG RR variability tests were performed to detect autonomic dysfunction. Results: Forty-two of 70 (60%) patients had abnormalities of cardiovascular reflex function of varying severity, whereas 24 of 34 (70%) had 24-h RR counts with the 95% age-related tolerance. The prevalence of abnormality increased with increasing severity of Liver disease but not with different etiologies. Conclusion: Irrespective of etiology, there is a high prevalence of autonomic dysfunction in cirrhosis, and it is related to disease severity: the mechanism is unknown.

AB - Objectives: To assess the prevalence of autonomic dysfunction in cirrhosis and to observe the effect of disease severity on autonomic dysfunction. Methods: Seventy patients with cirrhosis (Child's class A, 42; Child's class B, 10; and Child's class C, 15) (45 alcoholic, 15 primary biliary cirrhosis, five chronic active hepatitis, and eight idiopathic) underwent standard cardiovascular reflex tests. In addition, in 40 patients, 24-h ECG RR variability tests were performed to detect autonomic dysfunction. Results: Forty-two of 70 (60%) patients had abnormalities of cardiovascular reflex function of varying severity, whereas 24 of 34 (70%) had 24-h RR counts with the 95% age-related tolerance. The prevalence of abnormality increased with increasing severity of Liver disease but not with different etiologies. Conclusion: Irrespective of etiology, there is a high prevalence of autonomic dysfunction in cirrhosis, and it is related to disease severity: the mechanism is unknown.

M3 - Article

SN - 1572-0241

VL - 89

SP - 1544

EP - 1547

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

IS - 9

ER -