@article{5f65987d7b8e458db0a7594ffc6ce375,
title = "Autophagy in the eye: from physiology to pathophysology",
abstract = "Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging as a critical cellular pathway, involved in a variety of physiological and pathophysiological processes. Autophagy dysregulation is associated with an increasing number of diseases, including ocular diseases. On one hand, mutations in autophagy-related genes have been linked to cataracts, glaucoma, and corneal dystrophy; on the other hand, alterations in autophagy and lysosomal pathways are a common finding in essentially all diseases of the eye. Moreover, LC3-associated phagocytosis, a form of non-canonical autophagy, is critical in promoting visual cycle function. This review collects the latest understanding of autophagy in the context of the eye. We will review and discuss the respective roles of autophagy in the physiology and/or pathophysiology of each of the ocular tissues, its diurnal/circadian variation, as well as its involvement in diseases of the eye.",
keywords = "autophagy, eye, outflow pathway, trabecular meshwork, cornea, lens, photoreceptors, RPE, retinal epithelial cells, RGC, retina, retinal ganglion cells, glaucoma, eye diseases, AMD, corneal dystrophy, cataracts, vision cycle, lysosomes, dry eye, retinitis pigmentosa, retinal detachment",
author = "Liton, \{Paloma B.\} and Kathleen Boesze-Battaglia and Boulton, \{Michael E.\} and Patricia Boya and Ferguson, \{Thomas A.\} and Ganley, \{Ian G.\} and Anu Kauppinnen and Laurie, \{Gordon W.\} and Noboru Mizushima and Hideaki Morishita and Rossella Russo and Jaya Sadda and Rajalekshmy Shyam and Debasish Sinha and Thompson, \{Debra A.\} and Zacks, \{David N.\}",
note = "Funding Information: This work was supported by the National Eye Institute [EY026885, EY033600, EY005722]; National Eye Institute [EY026525]; National Eye Institute [EY034160]; Research to Prevent Blindness [Unrestricted to Washington University in St. Louis]; Research to Prevent Blindness [Stein Innovation Award]; Grant-in-Aid for Specially Promoted Research from the Japan Society for the Promotion of Science [22H04919]; Grant-in-Aid for Scientific Research (B) [20H03213]; Advanced Research and Development Programs for Medical Innovation [AMED-PRIME, 21gm6410019h0001]; National Eye Institute [EY032974]; National Eye Institute [EY020823]; Medical Research Council [IGG; MC\_UU\_00018/2]; National Eye Institute [EY026171, EY032956]; TearSolutions, Inc [Unrestricted gift]; Exploratory Research for Advanced Technology research funding program of the Japan Science and Technology Agency [JPMJER1702]; Research to Prevent Blindness [Unrestricted to Duke Dep. of Ophthalmology].Some of the figures have been generated using Biorender. Copyright: {\textcopyright} 2023 The Author(s). Published by Informa UK Limited, trading as Taylor \& Francis Group.",
year = "2023",
doi = "10.1080/27694127.2023.2178996",
language = "English",
volume = "2",
number = "1",
}