Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells

Linda V. Sinclair; Tom Youdale; Laura Spinelli; Milica Gakovic; Alistair J. Langlands; Shalini Pathak; Andrew J.M. Howden; Ian G. Ganley; Doreen A. Cantrell

doi:10.1038/s41590-025-02090-1

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells

Linda V. Sinclair (Lead / Corresponding author), Tom Youdale, Laura Spinelli, Milica Gakovic, Alistair J. Langlands, Shalini Pathak, Andrew J.M. Howden, Ian G. Ganley, Doreen A. Cantrell (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	429-443
Number of pages	32
Journal	Nature Immunology
Volume	26
DOIs	https://doi.org/10.1038/s41590-025-02090-1
Publication status	Published - 27 Feb 2025

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10.1038/s41590-025-02090-1Licence: CC BY

2 Finished
2 Active

System Level Understanding of Protein Degradation Pathways in T Lymphocytes
Cantrell, D. (Investigator)
1/06/24 → 31/05/32
Project: Research
Training the Next Generation of Scientists in Quantitative and Interdisciplinary Approaches to Biomedical Science (Doctoral Training Partnership)
Hunter, B. (Investigator) & MacKintosh, C. (Investigator)
Medical Research Council
11/11/16 → 30/09/25
Project: Research
Fluorescence Activated Cell Sorting for Cell Biology and Immunology (Equipment Grant)
Cantrell, D. (Investigator)
1/09/16 → 1/12/19
Project: Research

Cite this

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title = "Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells",

author = "Sinclair, {Linda V.} and Tom Youdale and Laura Spinelli and Milica Gakovic and Langlands, {Alistair J.} and Shalini Pathak and Howden, {Andrew J.M.} and Ganley, {Ian G.} and Cantrell, {Doreen A.}",

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doi = "10.1038/s41590-025-02090-1",

language = "English",

volume = "26",

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journal = "Nature Immunology",

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T1 - Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells

AU - Sinclair, Linda V.

AU - Youdale, Tom

AU - Spinelli, Laura

AU - Gakovic, Milica

AU - Langlands, Alistair J.

AU - Pathak, Shalini

AU - Howden, Andrew J.M.

AU - Ganley, Ian G.

AU - Cantrell, Doreen A.

PY - 2025/2/27

Y1 - 2025/2/27

U2 - 10.1038/s41590-025-02090-1

DO - 10.1038/s41590-025-02090-1

M3 - Article

SN - 1529-2908

VL - 26

SP - 429

EP - 443

JO - Nature Immunology

JF - Nature Immunology

ER -

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells

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Projects

System Level Understanding of Protein Degradation Pathways in T Lymphocytes

Training the Next Generation of Scientists in Quantitative and Interdisciplinary Approaches to Biomedical Science (Doctoral Training Partnership)

Fluorescence Activated Cell Sorting for Cell Biology and Immunology (Equipment Grant)

Cite this