Avascular growth, angiogenesis and vascular growth in solid tumours: the mathematical modelling of the stages of tumour development

M. A. J. Chaplain

    Research output: Contribution to journalArticlepeer-review

    182 Citations (Scopus)

    Abstract

    The growth and development of solid tumours occurs in two distinct stages—the avascular growth phase and the vascular growth phase. During the former growth phase the tumour remains in a diffusion-limited, dormant state of a few millimetres in diameter (cf. multicell spheroids, carcinoma in situ) while during the latter growth phase, invasion and metastasis may take place. In order to accomplish the transition from avascular to vascular growth, solid tumours may secrete diffusible substances known as tumour angiogenesis factors (TAF) into the surrounding tissue. Endothelial cells which form the lining of neighbouring blood vessels respond to this chemotactic stimulus in a well-ordered sequence of events. Capillary sprouts are formed which migrate towards the tumour, eventually penetrating it and permitting vascular growth to take place. This paper will present several mathematical models which deal with the various stages of growth and development of solid tumours.
    Original languageEnglish
    Pages (from-to)47-87
    Number of pages41
    JournalMathematical and Computer Modelling
    Volume23
    Issue number6
    DOIs
    Publication statusPublished - 1996

    Keywords

    • Avascular growth
    • Tumour angiogenesis
    • Vascular growth
    • Mathematical modelling

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