B-cell markers in the human kidney

This report describes the reactivity of a panel of 89 monoclonal antibodies with the normal human kidney. The antibodies were all submitted to the B-cell panel of the Third Leukocyte Differentiation Workshop. Several different patterns of staining of renal structures were identified. Most antibodies clustered in defined CD groups showed the same pattern of reactivity in the kidney, but some, notably CD19 antibodies, showed heterogeneity of binding to the kidney. These findings are important for the use of monoclonal antibodies to define phenotype in cell culture and immunohistology experiments.