B-type natriuretic peptide (BNP) increases the risk of death and cardiovascular events in patients without heart failure, even at BNP values within the "normal" range. The reasons for this are unclear.
Dawson, A., Davies, J. I., Morris, A. D., & Struthers, A. D. (2005). B-type natriuretic Peptide is associated with both augmentation index and left ventricular mass in diabetic patients without heart failure. American Journal of Hypertension, 18(12), 1586-1591. https://doi.org/10.1016/j.amjhyper.2005.06.016