B-type natriuretic peptide is associated with mortality in older functionally impaired patients

Miles D. Witham, Neil D. Gillespie, Stuart D. Hutcheon, Allan D. Struthers, Marion E. T. McMurdo

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    12 Citations (Scopus)


    Objectives: To determine the predictive power of B-type natriuretic peptide (BNP) regarding death in older, functionally impaired patients with multiple comorbidity. Design: Prospective cohort study. Setting: Specialist geriatric assessment clinic and day hospital. Participants: Two hundred ninety-nine older, functionally impaired patients, mean age 79 at enrollment. Measurements: Full clinical history and examination, baseline BNP, and echocardiography. Date and cause of death were ascertained from Scottish death records. Kaplan-Meier survival curves were constructed for quartiles of log (BNP), and the contribution of BNP to prediction of death was investigated. Results: The follow-up period ranged from 3.9 to 5.2 years (mean 4.4 years). BNP was a powerful independent predictor of all-cause and cardiovascular mortality. BNP was a more powerful predictor than blood pressure, diabetes mellitus, smoking, echocardiographic left ventricular hypertrophy, left ventricular systolic dysfunction, or age. BNP predicted death in those with and without a previous cardiovascular event at baseline. Conclusion: BNP has significant predictive power for death in older, functionally impaired patients.
    Original languageEnglish
    Pages (from-to)1991-1995
    Number of pages5
    JournalJournal of the American Geriatrics Society
    Issue number11
    Publication statusPublished - 2005


    • Aged
    • Natriuretic peptides
    • Mortality


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