B-type natriuretic peptide is associated with mortality in older functionally impaired patients

TY - JOUR

T1 - B-type natriuretic peptide is associated with mortality in older functionally impaired patients

AU - Witham, Miles D.

AU - Gillespie, Neil D.

AU - Hutcheon, Stuart D.

AU - Struthers, Allan D.

AU - McMurdo, Marion E. T.

N1 - dc.publisher: Wiley-Blackwell The definitive version is available at www3.interscience.wiley.com

PY - 2005

Y1 - 2005

N2 - Objectives: To determine the predictive power of B-type natriuretic peptide (BNP) regarding death in older, functionally impaired patients with multiple comorbidity. Design: Prospective cohort study. Setting: Specialist geriatric assessment clinic and day hospital. Participants: Two hundred ninety-nine older, functionally impaired patients, mean age 79 at enrollment. Measurements: Full clinical history and examination, baseline BNP, and echocardiography. Date and cause of death were ascertained from Scottish death records. Kaplan-Meier survival curves were constructed for quartiles of log (BNP), and the contribution of BNP to prediction of death was investigated. Results: The follow-up period ranged from 3.9 to 5.2 years (mean 4.4 years). BNP was a powerful independent predictor of all-cause and cardiovascular mortality. BNP was a more powerful predictor than blood pressure, diabetes mellitus, smoking, echocardiographic left ventricular hypertrophy, left ventricular systolic dysfunction, or age. BNP predicted death in those with and without a previous cardiovascular event at baseline. Conclusion: BNP has significant predictive power for death in older, functionally impaired patients.

AB - Objectives: To determine the predictive power of B-type natriuretic peptide (BNP) regarding death in older, functionally impaired patients with multiple comorbidity. Design: Prospective cohort study. Setting: Specialist geriatric assessment clinic and day hospital. Participants: Two hundred ninety-nine older, functionally impaired patients, mean age 79 at enrollment. Measurements: Full clinical history and examination, baseline BNP, and echocardiography. Date and cause of death were ascertained from Scottish death records. Kaplan-Meier survival curves were constructed for quartiles of log (BNP), and the contribution of BNP to prediction of death was investigated. Results: The follow-up period ranged from 3.9 to 5.2 years (mean 4.4 years). BNP was a powerful independent predictor of all-cause and cardiovascular mortality. BNP was a more powerful predictor than blood pressure, diabetes mellitus, smoking, echocardiographic left ventricular hypertrophy, left ventricular systolic dysfunction, or age. BNP predicted death in those with and without a previous cardiovascular event at baseline. Conclusion: BNP has significant predictive power for death in older, functionally impaired patients.

KW - Aged

KW - Natriuretic peptides

KW - Mortality

U2 - 10.1111/j.1532-5415.2005.53555.x

DO - 10.1111/j.1532-5415.2005.53555.x

M3 - Article

SN - 0002-8614

VL - 53

SP - 1991

EP - 1995

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

IS - 11

ER -