Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

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• Finished

  BACE1 and Endothelial Dysfunction in Diabetes (Project Grant scheme)

  Ashford, M. (Investigator) & Khan, F. (Investigator)

  British Heart Foundation

  1/10/15 → 30/09/18

  Project: Research

  • β-site APP-cleaving Enzyme 1 (BACE1) 100%
  • Amyloid Protein 56%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 53%
  • Kelch-like ECH-associated Protein 1 (Keap1) 53%
  • Transcription Factor Nrf2 53%

• Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity

  Ashford, M. (Investigator)

  Medical Research Council

  1/01/13 → 31/12/15

  Project: Research

  • β-site APP-cleaving Enzyme 1 (BACE1) 100%
  • Insulin Resistance 74%
  • Liver 52%
  • Amyloid Protein 48%
  • High-fat Diet 46%