TY - JOUR
T1 - Bacterial signal transduction by cyclic di-GMP and other nucleotide second messengers
AU - Hengge, Regine
AU - Gründling, Angelika
AU - Jenal, Urs
AU - Ryan, Robert
AU - Yildiz, Fitnat
N1 - Copyright © 2015, American Society for Microbiology. All Rights Reserved.
PY - 2016/1
Y1 - 2016/1
N2 - The first International Symposium on c-Di-GMP Signaling in Bacteria (22 to 25 March 2015, Harnack-Haus, Berlin, Germany) brought together 131 molecular microbiologists from 17 countries to discuss recent progress in our knowledge of bacterial nucleotide second messenger signaling. While the focus was on signal input, synthesis, degradation, and the striking diversity of the modes of action of the current second messenger paradigm, i.e., cyclic di-GMP (c-di-GMP), "classics" like cAMP and (p)ppGpp were also presented, in novel facets, and more recent "newcomers," such as c-di-AMP and c-AMP-GMP, made an impressive appearance. A number of clear trends emerged during the 30 talks, on the 71 posters, and in the lively discussions, including (i) c-di-GMP control of the activities of various ATPases and phosphorylation cascades, (ii) extensive cross talk between c-di-GMP and other nucleotide second messenger signaling pathways, and (iii) a stunning number of novel effectors for nucleotide second messengers that surprisingly include some long-known master regulators of developmental pathways. Overall, the conference made it amply clear that second messenger signaling is currently one of the most dynamic fields within molecular microbiology, with major impacts in research fields ranging from human health to microbial ecology.
AB - The first International Symposium on c-Di-GMP Signaling in Bacteria (22 to 25 March 2015, Harnack-Haus, Berlin, Germany) brought together 131 molecular microbiologists from 17 countries to discuss recent progress in our knowledge of bacterial nucleotide second messenger signaling. While the focus was on signal input, synthesis, degradation, and the striking diversity of the modes of action of the current second messenger paradigm, i.e., cyclic di-GMP (c-di-GMP), "classics" like cAMP and (p)ppGpp were also presented, in novel facets, and more recent "newcomers," such as c-di-AMP and c-AMP-GMP, made an impressive appearance. A number of clear trends emerged during the 30 talks, on the 71 posters, and in the lively discussions, including (i) c-di-GMP control of the activities of various ATPases and phosphorylation cascades, (ii) extensive cross talk between c-di-GMP and other nucleotide second messenger signaling pathways, and (iii) a stunning number of novel effectors for nucleotide second messengers that surprisingly include some long-known master regulators of developmental pathways. Overall, the conference made it amply clear that second messenger signaling is currently one of the most dynamic fields within molecular microbiology, with major impacts in research fields ranging from human health to microbial ecology.
UR - http://www.scopus.com/inward/record.url?scp=84953923744&partnerID=8YFLogxK
U2 - 10.1128/JB.00331-15
DO - 10.1128/JB.00331-15
M3 - Article
C2 - 26055111
VL - 198
SP - 15
EP - 26
JO - Journal of Bacteriology
JF - Journal of Bacteriology
SN - 0021-9193
IS - 1
T2 - International Symposium on c-di-GMP Signaling in Bacteria
Y2 - 22 March 2015 through 25 March 2015
ER -