Basal cell tetrasomy in low-grade cervical squamous intraepithelial lesions infected with high-risk human papillomaviruses

Shirley A.  Southern; Mark F. Evans; C. Simon  Herrington

Basal cell tetrasomy in low-grade cervical squamous intraepithelial lesions infected with high-risk human papillomaviruses

Shirley A. Southern
, Mark F. Evans
, C. Simon Herrington

Research output: Contribution to journal › Article › peer-review

Abstract

We have analyzed 60 low-grade cervical squamous intraepithelial lesions for low-and high-risk human papillomaviruses (HPVs) and for numerical abnormalities of chromosomes 1, 3, 11, 17, and 18 and the X chromosome, Eleven of 33 lesions infected with high-risk HPVs (HPV 16, 18, 30, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 66) but none of 24 lesions infected with low-risk HPVs (HPV 6, 11, 42, 43, and 44) and none of 15 normal cervices showed basal cell tetrasomy of all six chromosomes in the HPV-infefted areas, These changes were not HPV type specific and were not present in all lesions infected with the same HPV type, The presence of basal cell tetrasomy in lesions infected with high-hot not low-risk HPVs suggests that induction of chromosome instability may he one mechanism underlying the biological differences between these viral types.

Original language	English
Pages (from-to)	4210-4213
Number of pages	4
Journal	Cancer Research
Volume	57
Issue number	19
Publication status	Published - 1 Oct 1997

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title = "Basal cell tetrasomy in low-grade cervical squamous intraepithelial lesions infected with high-risk human papillomaviruses",

abstract = "We have analyzed 60 low-grade cervical squamous intraepithelial lesions for low-and high-risk human papillomaviruses (HPVs) and for numerical abnormalities of chromosomes 1, 3, 11, 17, and 18 and the X chromosome, Eleven of 33 lesions infected with high-risk HPVs (HPV 16, 18, 30, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 66) but none of 24 lesions infected with low-risk HPVs (HPV 6, 11, 42, 43, and 44) and none of 15 normal cervices showed basal cell tetrasomy of all six chromosomes in the HPV-infefted areas, These changes were not HPV type specific and were not present in all lesions infected with the same HPV type, The presence of basal cell tetrasomy in lesions infected with high-hot not low-risk HPVs suggests that induction of chromosome instability may he one mechanism underlying the biological differences between these viral types.",

author = "Southern, \{Shirley A.\} and Evans, \{Mark F.\} and Herrington, \{C. Simon\}",

year = "1997",

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T1 - Basal cell tetrasomy in low-grade cervical squamous intraepithelial lesions infected with high-risk human papillomaviruses

AU - Southern, Shirley A.

AU - Evans, Mark F.

AU - Herrington, C. Simon

PY - 1997/10/1

Y1 - 1997/10/1

N2 - We have analyzed 60 low-grade cervical squamous intraepithelial lesions for low-and high-risk human papillomaviruses (HPVs) and for numerical abnormalities of chromosomes 1, 3, 11, 17, and 18 and the X chromosome, Eleven of 33 lesions infected with high-risk HPVs (HPV 16, 18, 30, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 66) but none of 24 lesions infected with low-risk HPVs (HPV 6, 11, 42, 43, and 44) and none of 15 normal cervices showed basal cell tetrasomy of all six chromosomes in the HPV-infefted areas, These changes were not HPV type specific and were not present in all lesions infected with the same HPV type, The presence of basal cell tetrasomy in lesions infected with high-hot not low-risk HPVs suggests that induction of chromosome instability may he one mechanism underlying the biological differences between these viral types.

AB - We have analyzed 60 low-grade cervical squamous intraepithelial lesions for low-and high-risk human papillomaviruses (HPVs) and for numerical abnormalities of chromosomes 1, 3, 11, 17, and 18 and the X chromosome, Eleven of 33 lesions infected with high-risk HPVs (HPV 16, 18, 30, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 66) but none of 24 lesions infected with low-risk HPVs (HPV 6, 11, 42, 43, and 44) and none of 15 normal cervices showed basal cell tetrasomy of all six chromosomes in the HPV-infefted areas, These changes were not HPV type specific and were not present in all lesions infected with the same HPV type, The presence of basal cell tetrasomy in lesions infected with high-hot not low-risk HPVs suggests that induction of chromosome instability may he one mechanism underlying the biological differences between these viral types.

M3 - Article

SN - 0008-5472

VL - 57

SP - 4210

EP - 4213

JO - Cancer Research

JF - Cancer Research

IS - 19

ER -

Basal cell tetrasomy in low-grade cervical squamous intraepithelial lesions infected with high-risk human papillomaviruses

Abstract

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