Basal Instinct: Persistence of Barrier Dysfunction

Caroline Chauché, Henry J. McSorley (Lead / Corresponding author)

Research output: Contribution to journalShort survey

Abstract

In a recent issue of Nature, Ordovas-Montanes et al. (2018) used cutting-edge genomic, epigenetic, and interventional techniques to characterize the cellular ecosystem in allergic chronic rhinosinusitis. They showed that basal epithelial cells “remember” type 2 inflammatory stimuli to maintain a chronic allergic disease phenotype. In a recent issue of Nature, Ordovas-Montanes et al. (2018) used cutting-edge genomic, epigenetic, and interventional techniques to characterize the cellular ecosystem in allergic chronic rhinosinusitis. They showed that basal epithelial cells “remember” type 2 inflammatory stimuli to maintain a chronic allergic disease phenotype.

Original languageEnglish
Pages (from-to)590-592
Number of pages3
JournalImmunity
Volume49
Issue number4
Early online date16 Oct 2018
DOIs
Publication statusPublished - 16 Oct 2018

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