Basic pharmacology of local anaesthetics

A. Taylor, G. McLeod

Research output: Contribution to journalReview article


Local anaesthetic agents suppress action potentials in excitable tissues by blocking voltage-gated Naþ channels. In doing so, they inhibit action potentials in nociceptive fibres and so block the transmission of pain impulses. This article describes nerve anatomy and physiology, the molecular site of action of local anaesthetics, and their pharmacology.
Original languageEnglish
Pages (from-to)34-41
Number of pages8
JournalBJA Education
Issue number2
Early online date4 Dec 2019
Publication statusPublished - Feb 2020


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