Basic pharmacology of local anaesthetics

A. Taylor; G. McLeod

doi:10.1016/j.bjae.2019.10.002

Basic pharmacology of local anaesthetics

A. Taylor
, G. McLeod

Research output: Contribution to journal › Review article › peer-review

195 Citations (Scopus)

Abstract

Local anaesthetic agents suppress action potentials in excitable tissues by blocking voltage-gated Naþ channels. In doing so, they inhibit action potentials in nociceptive fibres and so block the transmission of pain impulses. This article describes nerve anatomy and physiology, the molecular site of action of local anaesthetics, and their pharmacology.

Original language	English
Pages (from-to)	34-41
Number of pages	8
Journal	BJA Education
Volume	20
Issue number	2
Early online date	4 Dec 2019
DOIs	https://doi.org/10.1016/j.bjae.2019.10.002
Publication status	Published - Feb 2020

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1016/j.bjae.2019.10.002Licence: Elsevier User Licence

https://www.sciencedirect.com/science/article/pii/S2058534919301520Licence: Elsevier User Licence

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title = "Basic pharmacology of local anaesthetics",

abstract = "Local anaesthetic agents suppress action potentials in excitable tissues by blocking voltage-gated Na{\th} channels. In doing so, they inhibit action potentials in nociceptive fibres and so block the transmission of pain impulses. This article describes nerve anatomy and physiology, the molecular site of action of local anaesthetics, and their pharmacology.",

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AU - Taylor, A.

AU - McLeod, G.

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AB - Local anaesthetic agents suppress action potentials in excitable tissues by blocking voltage-gated Naþ channels. In doing so, they inhibit action potentials in nociceptive fibres and so block the transmission of pain impulses. This article describes nerve anatomy and physiology, the molecular site of action of local anaesthetics, and their pharmacology.

UR - https://www.scopus.com/pages/publications/85076225226

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DO - 10.1016/j.bjae.2019.10.002

M3 - Review article

C2 - 33456928

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JO - BJA Education

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Basic pharmacology of local anaesthetics

Abstract

ASJC Scopus subject areas

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Corrigendum to ‘Basic pharmacology of local anaesthetics’ [BJA Education 20 (2020) 34–41] (BJA Education (2020) 20(2) (34–41), (S2058534919301520), (10.1016/j.bjae.2019.10.002))

Cite this