Benefits of supervised group exercise programme for women being treated for early stage breast cancer

pragmatic randomised controlled trial

Nanette Mutrie, Anna M. Campbell, Fiona Whyte, Alex McConnachie, Carol Emslie, Laura Lee, Nora Kearney, Andrew Walker, Diana Ritchie

    Research output: Contribution to journalArticle

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    Abstract

    Objectives To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up. Design Pragmatic randomised controlled prospective open trial. Setting Three National Health Service oncology clinics in Scotland and community exercise facilities. Participants 203 women entered the study; 177 completed the six month follow-up. Interventions Supervised 12 week group exercise programme in addition to usual care, compared with usual care. Main outcome measures Functional assessment of cancer therapy (FACT) questionnaire, Beck depression inventory, positive and negative affect scale, body mass index, seven day recall of physical activity, 12 minute walk test, and assessment of shoulder mobility. Results Mixed effects models with adjustment for baseline values, study site, treatment at baseline, and age gave intervention effect estimates (intervention minus control) at 12 weeks of 129 (95% confidence interval 83 to 176) for metres walked in 12 minutes, 182 (75 to 289) for minutes of moderate intensity activity reported in a week, 2.6 (1.6 to 3.7) for shoulder mobility, 2.5 (1.0 to 3.9) for breast cancer specific subscale of quality of life, and 4.0 (1.8 to 6.3) for positive mood. No significant effect was seen for general quality of life (FACT-G), which was the primary outcome. At the six month follow-up, most of these effects were maintained and an intervention effect for breast cancer specific quality of life emerged. No adverse effects were noted. Conclusion Supervised group exercise provided functional and psychological benefit after a 12 week intervention and six months later. Clinicians should encourage activity for their patients. Policy makers should consider the inclusion of exercise opportunities in cancer rehabilitation services. Trial registration Current controlled trials ISRCTN12587864.
    Original languageEnglish
    Pages (from-to)517-520
    Number of pages4
    JournalBMJ
    Volume334
    Issue number7592
    DOIs
    Publication statusPublished - 2007

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    Randomized Controlled Trials
    Exercise
    Breast Neoplasms
    Quality of Life
    Psychology
    Neoplasms
    National Health Programs
    Scotland
    Therapeutics
    Administrative Personnel
    Body Mass Index
    Rehabilitation
    Outcome Assessment (Health Care)
    Confidence Intervals
    Depression
    Equipment and Supplies

    Cite this

    Mutrie, N., Campbell, A. M., Whyte, F., McConnachie, A., Emslie, C., Lee, L., ... Ritchie, D. (2007). Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial. BMJ, 334(7592), 517-520. https://doi.org/10.1136/bmj.39094.648553.AE
    Mutrie, Nanette ; Campbell, Anna M. ; Whyte, Fiona ; McConnachie, Alex ; Emslie, Carol ; Lee, Laura ; Kearney, Nora ; Walker, Andrew ; Ritchie, Diana. / Benefits of supervised group exercise programme for women being treated for early stage breast cancer : pragmatic randomised controlled trial. In: BMJ. 2007 ; Vol. 334, No. 7592. pp. 517-520.
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    abstract = "Objectives To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up. Design Pragmatic randomised controlled prospective open trial. Setting Three National Health Service oncology clinics in Scotland and community exercise facilities. Participants 203 women entered the study; 177 completed the six month follow-up. Interventions Supervised 12 week group exercise programme in addition to usual care, compared with usual care. Main outcome measures Functional assessment of cancer therapy (FACT) questionnaire, Beck depression inventory, positive and negative affect scale, body mass index, seven day recall of physical activity, 12 minute walk test, and assessment of shoulder mobility. Results Mixed effects models with adjustment for baseline values, study site, treatment at baseline, and age gave intervention effect estimates (intervention minus control) at 12 weeks of 129 (95{\%} confidence interval 83 to 176) for metres walked in 12 minutes, 182 (75 to 289) for minutes of moderate intensity activity reported in a week, 2.6 (1.6 to 3.7) for shoulder mobility, 2.5 (1.0 to 3.9) for breast cancer specific subscale of quality of life, and 4.0 (1.8 to 6.3) for positive mood. No significant effect was seen for general quality of life (FACT-G), which was the primary outcome. At the six month follow-up, most of these effects were maintained and an intervention effect for breast cancer specific quality of life emerged. No adverse effects were noted. Conclusion Supervised group exercise provided functional and psychological benefit after a 12 week intervention and six months later. Clinicians should encourage activity for their patients. Policy makers should consider the inclusion of exercise opportunities in cancer rehabilitation services. Trial registration Current controlled trials ISRCTN12587864.",
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    Mutrie, N, Campbell, AM, Whyte, F, McConnachie, A, Emslie, C, Lee, L, Kearney, N, Walker, A & Ritchie, D 2007, 'Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial', BMJ, vol. 334, no. 7592, pp. 517-520. https://doi.org/10.1136/bmj.39094.648553.AE

    Benefits of supervised group exercise programme for women being treated for early stage breast cancer : pragmatic randomised controlled trial. / Mutrie, Nanette; Campbell, Anna M.; Whyte, Fiona; McConnachie, Alex; Emslie, Carol; Lee, Laura; Kearney, Nora; Walker, Andrew; Ritchie, Diana.

    In: BMJ, Vol. 334, No. 7592, 2007, p. 517-520.

    Research output: Contribution to journalArticle

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    T1 - Benefits of supervised group exercise programme for women being treated for early stage breast cancer

    T2 - pragmatic randomised controlled trial

    AU - Mutrie, Nanette

    AU - Campbell, Anna M.

    AU - Whyte, Fiona

    AU - McConnachie, Alex

    AU - Emslie, Carol

    AU - Lee, Laura

    AU - Kearney, Nora

    AU - Walker, Andrew

    AU - Ritchie, Diana

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    Y1 - 2007

    N2 - Objectives To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up. Design Pragmatic randomised controlled prospective open trial. Setting Three National Health Service oncology clinics in Scotland and community exercise facilities. Participants 203 women entered the study; 177 completed the six month follow-up. Interventions Supervised 12 week group exercise programme in addition to usual care, compared with usual care. Main outcome measures Functional assessment of cancer therapy (FACT) questionnaire, Beck depression inventory, positive and negative affect scale, body mass index, seven day recall of physical activity, 12 minute walk test, and assessment of shoulder mobility. Results Mixed effects models with adjustment for baseline values, study site, treatment at baseline, and age gave intervention effect estimates (intervention minus control) at 12 weeks of 129 (95% confidence interval 83 to 176) for metres walked in 12 minutes, 182 (75 to 289) for minutes of moderate intensity activity reported in a week, 2.6 (1.6 to 3.7) for shoulder mobility, 2.5 (1.0 to 3.9) for breast cancer specific subscale of quality of life, and 4.0 (1.8 to 6.3) for positive mood. No significant effect was seen for general quality of life (FACT-G), which was the primary outcome. At the six month follow-up, most of these effects were maintained and an intervention effect for breast cancer specific quality of life emerged. No adverse effects were noted. Conclusion Supervised group exercise provided functional and psychological benefit after a 12 week intervention and six months later. Clinicians should encourage activity for their patients. Policy makers should consider the inclusion of exercise opportunities in cancer rehabilitation services. Trial registration Current controlled trials ISRCTN12587864.

    AB - Objectives To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up. Design Pragmatic randomised controlled prospective open trial. Setting Three National Health Service oncology clinics in Scotland and community exercise facilities. Participants 203 women entered the study; 177 completed the six month follow-up. Interventions Supervised 12 week group exercise programme in addition to usual care, compared with usual care. Main outcome measures Functional assessment of cancer therapy (FACT) questionnaire, Beck depression inventory, positive and negative affect scale, body mass index, seven day recall of physical activity, 12 minute walk test, and assessment of shoulder mobility. Results Mixed effects models with adjustment for baseline values, study site, treatment at baseline, and age gave intervention effect estimates (intervention minus control) at 12 weeks of 129 (95% confidence interval 83 to 176) for metres walked in 12 minutes, 182 (75 to 289) for minutes of moderate intensity activity reported in a week, 2.6 (1.6 to 3.7) for shoulder mobility, 2.5 (1.0 to 3.9) for breast cancer specific subscale of quality of life, and 4.0 (1.8 to 6.3) for positive mood. No significant effect was seen for general quality of life (FACT-G), which was the primary outcome. At the six month follow-up, most of these effects were maintained and an intervention effect for breast cancer specific quality of life emerged. No adverse effects were noted. Conclusion Supervised group exercise provided functional and psychological benefit after a 12 week intervention and six months later. Clinicians should encourage activity for their patients. Policy makers should consider the inclusion of exercise opportunities in cancer rehabilitation services. Trial registration Current controlled trials ISRCTN12587864.

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