Beta-adrenoceptor antagonists enhance white blood cell aggregation in patients with ischaemic heart disease

A. B. Bridges, T. H. Pringle, G. P. McNeill, R. Tavendale, J. J. Belch

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The effects of beta-adrenoceptor antagonists, calcium channel blockers and long acting nitrates on white blood cell (WBC) aggregation were studied in patients with ischaemic heart disease. WBC aggregation was significantly increased by beta-adrenoceptor antagonists (P = 0.011) but was unaffected by either calcium channel blockers or long acting nitrates. Enhanced WBC aggregation promotes microvascular occlusion and damage.
    Original languageEnglish
    Pages (from-to)272-274
    Number of pages3
    JournalBritish Journal of Clinical Pharmacology
    Volume34
    Issue number3
    DOIs
    Publication statusPublished - Sep 1992

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