Beta-adrenoceptor antagonists enhance white blood cell aggregation in patients with ischaemic heart disease

A. B. Bridges; T. H. Pringle; G. P. McNeill; R. Tavendale; J. J. Belch

doi:10.1111/j.1365-2125.1992.tb04137.x

Beta-adrenoceptor antagonists enhance white blood cell aggregation in patients with ischaemic heart disease

A. B. Bridges, T. H. Pringle, G. P. McNeill, R. Tavendale, J. J. Belch

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of beta-adrenoceptor antagonists, calcium channel blockers and long acting nitrates on white blood cell (WBC) aggregation were studied in patients with ischaemic heart disease. WBC aggregation was significantly increased by beta-adrenoceptor antagonists (P = 0.011) but was unaffected by either calcium channel blockers or long acting nitrates. Enhanced WBC aggregation promotes microvascular occlusion and damage.

Original language	English
Pages (from-to)	272-274
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	34
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2125.1992.tb04137.x
Publication status	Published - Sept 1992

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10.1111/j.1365-2125.1992.tb04137.x

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title = "Beta-adrenoceptor antagonists enhance white blood cell aggregation in patients with ischaemic heart disease",

abstract = "The effects of beta-adrenoceptor antagonists, calcium channel blockers and long acting nitrates on white blood cell (WBC) aggregation were studied in patients with ischaemic heart disease. WBC aggregation was significantly increased by beta-adrenoceptor antagonists (P = 0.011) but was unaffected by either calcium channel blockers or long acting nitrates. Enhanced WBC aggregation promotes microvascular occlusion and damage.",

author = "Bridges, {A. B.} and Pringle, {T. H.} and McNeill, {G. P.} and R. Tavendale and Belch, {J. J.}",

year = "1992",

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AU - Bridges, A. B.

AU - Pringle, T. H.

AU - McNeill, G. P.

AU - Tavendale, R.

AU - Belch, J. J.

PY - 1992/9

Y1 - 1992/9

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AB - The effects of beta-adrenoceptor antagonists, calcium channel blockers and long acting nitrates on white blood cell (WBC) aggregation were studied in patients with ischaemic heart disease. WBC aggregation was significantly increased by beta-adrenoceptor antagonists (P = 0.011) but was unaffected by either calcium channel blockers or long acting nitrates. Enhanced WBC aggregation promotes microvascular occlusion and damage.

U2 - 10.1111/j.1365-2125.1992.tb04137.x

DO - 10.1111/j.1365-2125.1992.tb04137.x

M3 - Article

C2 - 1356405

SN - 0306-5251

VL - 34

SP - 272

EP - 274

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 3

ER -

Beta-adrenoceptor antagonists enhance white blood cell aggregation in patients with ischaemic heart disease

Abstract

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