Bi-component conformal electrode for radiofrequency sequential ablation and circumferential separation of large tumours in solid organs

development and in-vitro evaluation

Zhigang Wang, Hongyan Luo, Stuart Coleman, Alfred Cuschieri

    Research output: Contribution to journalArticle

    3 Citations (Scopus)
    111 Downloads (Pure)

    Abstract

    Objective: Complete destruction of large tumours by radiofrequency ablation (RFA) with surrounding tumour-free margin is difficult because of incomplete or non-uniform heating due to both heat sink effect of circulating blood and limitations of existing RF electrode design. A new RF electrode is described to overcome this limitation. Methods: A bi-component conformal (BCC) RFA probe providing sectorial sequential ablation followed by circumferential cutting is designed and evaluated. Three-dimensional finite-element analysis model was developed with temperature feedback-controlled simulation of RFA for electrode design and optimization. The prototype bipolar BCC probe with 3 embedded thermocouples was constructed and evaluated in tissue-mimicking phantoms. Results: Maximum tissue temperature was kept < 100 ºC with power applied < 15 W. A 10 min ablation time was used for each sequence and after four sequential RFA, a large ablation zone of 55 cm3 was achieved. Our experiment confirmed that lesions exceeding 3.7cm could be ablated and separated from the surrounded tissue. Conclusion: The new BCC probe is thus capable of controlled ablation followed by circumferential separation of the lesions, when required. Significance: The results of these experiments provide proof of concept validation that the BCC probe has the potential to ablate by sequential heating tumours in solid organs > 3.5cm then separate them by electrosurgical cutting from the surrounding normal parenchyma. The combined RF ablation and physical separation could completely destroy the cancer cells at the ablation site thus avoid any local recurrence of cancer. It requires further in-vivo validation studies in large animals.
    Original languageEnglish
    Pages (from-to)699-705
    Number of pages7
    JournalIEEE Transactions on Biomedical Engineering
    Volume64
    Issue number3
    Early online date25 May 2016
    DOIs
    Publication statusPublished - Mar 2017

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    Ablation
    Tumors
    Electrodes
    Tissue
    Heat sinks
    Thermocouples
    Animals
    Blood
    Cells
    Feedback
    Finite element method
    Heating
    Temperature

    Keywords

    • Bipolar electrode
    • finite element method (FEM)
    • radiofrequency ablation (RFA)
    • tissue-mimicking phantom

    Cite this

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    title = "Bi-component conformal electrode for radiofrequency sequential ablation and circumferential separation of large tumours in solid organs: development and in-vitro evaluation",
    abstract = "Objective: Complete destruction of large tumours by radiofrequency ablation (RFA) with surrounding tumour-free margin is difficult because of incomplete or non-uniform heating due to both heat sink effect of circulating blood and limitations of existing RF electrode design. A new RF electrode is described to overcome this limitation. Methods: A bi-component conformal (BCC) RFA probe providing sectorial sequential ablation followed by circumferential cutting is designed and evaluated. Three-dimensional finite-element analysis model was developed with temperature feedback-controlled simulation of RFA for electrode design and optimization. The prototype bipolar BCC probe with 3 embedded thermocouples was constructed and evaluated in tissue-mimicking phantoms. Results: Maximum tissue temperature was kept < 100 ºC with power applied < 15 W. A 10 min ablation time was used for each sequence and after four sequential RFA, a large ablation zone of 55 cm3 was achieved. Our experiment confirmed that lesions exceeding 3.7cm could be ablated and separated from the surrounded tissue. Conclusion: The new BCC probe is thus capable of controlled ablation followed by circumferential separation of the lesions, when required. Significance: The results of these experiments provide proof of concept validation that the BCC probe has the potential to ablate by sequential heating tumours in solid organs > 3.5cm then separate them by electrosurgical cutting from the surrounding normal parenchyma. The combined RF ablation and physical separation could completely destroy the cancer cells at the ablation site thus avoid any local recurrence of cancer. It requires further in-vivo validation studies in large animals.",
    keywords = "Bipolar electrode, finite element method (FEM), radiofrequency ablation (RFA), tissue-mimicking phantom",
    author = "Zhigang Wang and Hongyan Luo and Stuart Coleman and Alfred Cuschieri",
    year = "2017",
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    doi = "10.1109/TBME.2016.2573043",
    language = "English",
    volume = "64",
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    journal = "IEEE Transactions on Biomedical Engineering",
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    }

    TY - JOUR

    T1 - Bi-component conformal electrode for radiofrequency sequential ablation and circumferential separation of large tumours in solid organs

    T2 - development and in-vitro evaluation

    AU - Wang, Zhigang

    AU - Luo, Hongyan

    AU - Coleman, Stuart

    AU - Cuschieri, Alfred

    PY - 2017/3

    Y1 - 2017/3

    N2 - Objective: Complete destruction of large tumours by radiofrequency ablation (RFA) with surrounding tumour-free margin is difficult because of incomplete or non-uniform heating due to both heat sink effect of circulating blood and limitations of existing RF electrode design. A new RF electrode is described to overcome this limitation. Methods: A bi-component conformal (BCC) RFA probe providing sectorial sequential ablation followed by circumferential cutting is designed and evaluated. Three-dimensional finite-element analysis model was developed with temperature feedback-controlled simulation of RFA for electrode design and optimization. The prototype bipolar BCC probe with 3 embedded thermocouples was constructed and evaluated in tissue-mimicking phantoms. Results: Maximum tissue temperature was kept < 100 ºC with power applied < 15 W. A 10 min ablation time was used for each sequence and after four sequential RFA, a large ablation zone of 55 cm3 was achieved. Our experiment confirmed that lesions exceeding 3.7cm could be ablated and separated from the surrounded tissue. Conclusion: The new BCC probe is thus capable of controlled ablation followed by circumferential separation of the lesions, when required. Significance: The results of these experiments provide proof of concept validation that the BCC probe has the potential to ablate by sequential heating tumours in solid organs > 3.5cm then separate them by electrosurgical cutting from the surrounding normal parenchyma. The combined RF ablation and physical separation could completely destroy the cancer cells at the ablation site thus avoid any local recurrence of cancer. It requires further in-vivo validation studies in large animals.

    AB - Objective: Complete destruction of large tumours by radiofrequency ablation (RFA) with surrounding tumour-free margin is difficult because of incomplete or non-uniform heating due to both heat sink effect of circulating blood and limitations of existing RF electrode design. A new RF electrode is described to overcome this limitation. Methods: A bi-component conformal (BCC) RFA probe providing sectorial sequential ablation followed by circumferential cutting is designed and evaluated. Three-dimensional finite-element analysis model was developed with temperature feedback-controlled simulation of RFA for electrode design and optimization. The prototype bipolar BCC probe with 3 embedded thermocouples was constructed and evaluated in tissue-mimicking phantoms. Results: Maximum tissue temperature was kept < 100 ºC with power applied < 15 W. A 10 min ablation time was used for each sequence and after four sequential RFA, a large ablation zone of 55 cm3 was achieved. Our experiment confirmed that lesions exceeding 3.7cm could be ablated and separated from the surrounded tissue. Conclusion: The new BCC probe is thus capable of controlled ablation followed by circumferential separation of the lesions, when required. Significance: The results of these experiments provide proof of concept validation that the BCC probe has the potential to ablate by sequential heating tumours in solid organs > 3.5cm then separate them by electrosurgical cutting from the surrounding normal parenchyma. The combined RF ablation and physical separation could completely destroy the cancer cells at the ablation site thus avoid any local recurrence of cancer. It requires further in-vivo validation studies in large animals.

    KW - Bipolar electrode

    KW - finite element method (FEM)

    KW - radiofrequency ablation (RFA)

    KW - tissue-mimicking phantom

    U2 - 10.1109/TBME.2016.2573043

    DO - 10.1109/TBME.2016.2573043

    M3 - Article

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    JO - IEEE Transactions on Biomedical Engineering

    JF - IEEE Transactions on Biomedical Engineering

    SN - 0018-9294

    IS - 3

    ER -