Bi-orienting chromosomes on the mitotic spindle

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    52 Citations (Scopus)

    Abstract

    For the proper segregation of sister chromatids before cell division, each sister kinetochore must attach to microtubules that extend to opposite spindle poles. This process is called bipolar microtubule attachment or chromosome bi-orientation. The mechanism for chromosome bi-orientation lies at the heart of chromosome segregation, but is still poorly understood. Recent studies suggest that cells can promote bi-orientation by re-orienting kinetochore-spindle pole connections.
    Original languageEnglish
    Pages (from-to)365-71
    Number of pages7
    JournalCurrent Opinion in Cell Biology
    Volume14
    Issue number3
    DOIs
    Publication statusPublished - 2002

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