Bi-orienting chromosomes on the mitotic spindle

TY - JOUR

T1 - Bi-orienting chromosomes on the mitotic spindle

AU - Tanaka, Tomoyuki U

PY - 2002

Y1 - 2002

N2 - For the proper segregation of sister chromatids before cell division, each sister kinetochore must attach to microtubules that extend to opposite spindle poles. This process is called bipolar microtubule attachment or chromosome bi-orientation. The mechanism for chromosome bi-orientation lies at the heart of chromosome segregation, but is still poorly understood. Recent studies suggest that cells can promote bi-orientation by re-orienting kinetochore-spindle pole connections.

AB - For the proper segregation of sister chromatids before cell division, each sister kinetochore must attach to microtubules that extend to opposite spindle poles. This process is called bipolar microtubule attachment or chromosome bi-orientation. The mechanism for chromosome bi-orientation lies at the heart of chromosome segregation, but is still poorly understood. Recent studies suggest that cells can promote bi-orientation by re-orienting kinetochore-spindle pole connections.

U2 - 10.1016/S0955-0674(02)00328-9

DO - 10.1016/S0955-0674(02)00328-9

M3 - Article

C2 - 12067660

SN - 0955-0674

VL - 14

SP - 365

EP - 371

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 3

ER -