BIFUNCTIONAL MOLECULES FOR TARGETING RPN11

Alessio Ciulli; Andrea Testa; Scott Hughes; Steven Peter Butcher

BIFUNCTIONAL MOLECULES FOR TARGETING RPN11

Alessio Ciulli (Inventor), Andrea Testa (Inventor), Scott Hughes (Inventor), Steven Peter Butcher (Inventor)

Biological Chemistry and Drug Discovery

Research output: Patent

Abstract

The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Original language	English
Patent number	WO/2019/238817
Priority date	13/06/18
Filing date	13/06/19
Publication status	Published - 19 Dec 2019

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https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019238817Licence: No Licence / Unknown

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title = "BIFUNCTIONAL MOLECULES FOR TARGETING RPN11",

abstract = "The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.",

author = "Alessio Ciulli and Andrea Testa and Scott Hughes and Butcher, {Steven Peter}",

year = "2019",

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day = "19",

language = "English",

type = "Patent",

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TY - PAT

T1 - BIFUNCTIONAL MOLECULES FOR TARGETING RPN11

AU - Ciulli, Alessio

AU - Testa, Andrea

AU - Hughes, Scott

AU - Butcher, Steven Peter

PY - 2019/12/19

Y1 - 2019/12/19

N2 - The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

AB - The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

M3 - Patent

M1 - WO/2019/238817

Y2 - 2019/06/13

ER -

BIFUNCTIONAL MOLECULES FOR TARGETING RPN11

Abstract

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