BIFUNCTIONAL MOLECULES FOR TARGETING USP14

Andrea Testa; Scott Hughes; Steven Peter Butcher; Alessio Ciulli

BIFUNCTIONAL MOLECULES FOR TARGETING USP14

Andrea Testa (Inventor), Scott Hughes (Inventor), Steven Peter Butcher (Inventor), Alessio Ciulli (Inventor)

Biological Chemistry and Drug Discovery

Research output: Patent

Abstract

The invention provides for bifunctional molecules comprising an Usp14 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Usp14 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Original language	English
Patent number	WO/2019/238886
Filing date	13/06/19
Publication status	Published - 19 Dec 2019

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title = "BIFUNCTIONAL MOLECULES FOR TARGETING USP14",

abstract = "The invention provides for bifunctional molecules comprising an Usp14 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Usp14 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.",

author = "Andrea Testa and Scott Hughes and Butcher, {Steven Peter} and Alessio Ciulli",

year = "2019",

month = dec,

day = "19",

language = "English",

type = "Patent",

note = "WO/2019/238886",

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TY - PAT

T1 - BIFUNCTIONAL MOLECULES FOR TARGETING USP14

AU - Testa, Andrea

AU - Hughes, Scott

AU - Butcher, Steven Peter

AU - Ciulli, Alessio

PY - 2019/12/19

Y1 - 2019/12/19

N2 - The invention provides for bifunctional molecules comprising an Usp14 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Usp14 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

AB - The invention provides for bifunctional molecules comprising an Usp14 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Usp14 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

M3 - Patent

M1 - WO/2019/238886

Y2 - 2019/06/13

ER -

BIFUNCTIONAL MOLECULES FOR TARGETING USP14

Abstract

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