Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

Agne Kazlauskaite, R Julio Martínez-Torres, Scott Wilkie, Atul Kumar, Julien Peltier, Alba Gonzalez, Clare Johnson, Jinwei Zhang, Anthony G Hope, Mark Peggie, Matthias Trost, Daan Mf van Aalten, Dario R Alessi, Alan R Prescott, Axel Knebel, Helen Walden, Miratul MK Muqit (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

148 Citations (Scopus)

177 Downloads (Pure)

1 Active
8 Finished

9 results

Active
Biochemical Analysis of the PINK-1 Parkin Signalling Pathway in Parkinson's Disease (Senior Clinical Fellowship)
Muqit, M.
Wellcome Trust
1/07/13 → 31/12/23
Project: Research
Finished
Structural Analysis of the Parkinson's Associated Kinase PINK1
Muqit, M. & van Aalten, D.
Parkinson's UK
1/11/15 → 31/10/16
Project: Research
Investigation of the Regulation of Rab GTPases by PINK1 (PhD Studentship)
Muqit, M.
Parkinson's UK
7/09/15 → 6/09/18
Project: Research
Study of Differential TRNA Post-Transcriptional Modifications as a Mechanism to Control Proteome Composition
Alessi, D. & Pedrioli, P.
Biotechnology and Biological Sciences Research Council
31/03/14 → 30/03/17
Project: Research
Strategic Award: Wellcome Trust Technology Platform
Blow, J., Lamond, A. & Owen-Hughes, T.
Wellcome Trust
1/01/13 → 30/09/18
Project: Research
Role of fbx07 in Parkinson's Disease (Studentship)
Alessi, D.
1/10/11 → 30/09/15
Project: Research
Aref#d: 21286. Mass Spectrometry-Based Global Analysis of Protein Phosphorylation in Cells and Tissue Extracts with Altered PINK1 Catalytic Activity: A Novel Screen for PINK1 Substrates
Alessi, D. & Muqit, M.
1/12/09 → 30/11/12
Project: Research
Aref#d: 21559. Molecular Mechanisms of Fungal Cell Wall Assembly (Programme Grant)
van Aalten, D.
Medical Research Council
1/11/09 → 31/10/14
Project: Research
Aref#d: 21318. Molecular Mechanisms of O-GlcNAc Signalling (Senior Fellowship Renewal)
van Aalten, D.
Wellcome Trust
1/06/09 → 29/02/16
Project: Research