Bioactive polymethoxylated flavonoids from Chiliadenus montanus

Ahmed R. Hamed (Lead / Corresponding author), Tarik A. Mohamed, Wafaa A. Tawfik, Emad M. Hassan, Maureen Higgins, Sayed A. El-Toumy, Albena T. Dinkova-Kostova

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    Abstract

    Phytochemical investigations of the CH2Cl2/MeOH (1:1) extract of air-dried aerial parts of Chiliadenus montanus afforded seven methoxylated flavonoids (1-7), three of them were isolated for the first time from the genus (1-3). Structures were established by spectroscopic methods, including HREIMS,1H,13C, DEPT,1H-1H COSY, HMQC and HMBC NMR analyses. In the present study, three of the isolated compounds were tested for the ability to induce NAD(P)H:quinoneoxidoreductase 1 (NQO1) using a quantitative bioassay in a murine hepatoma cell line. Compound 1 revealed dose-dependent NQO1 inducing properties with a concentration that doubled the specific enzyme activity by 2-fold (CD value) of 7.0 µM, and a magnitude of induction of 3.3-fold at the highest concentration tested (100 µM).

    Original languageEnglish
    Pages (from-to)788-793
    Number of pages6
    JournalJournal of Chemical and Pharmaceutical Research
    Volume8
    Issue number3
    Publication statusPublished - 31 Mar 2016

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    Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A., & Dinkova-Kostova, A. T. (2016). Bioactive polymethoxylated flavonoids from Chiliadenus montanus. Journal of Chemical and Pharmaceutical Research, 8(3), 788-793.