Bioactive polymethoxylated flavonoids from Chiliadenus montanus

Ahmed R. Hamed (Lead / Corresponding author), Tarik A. Mohamed, Wafaa A. Tawfik, Emad M. Hassan, Maureen Higgins, Sayed A. El-Toumy, Albena T. Dinkova-Kostova

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    Phytochemical investigations of the CH2Cl2/MeOH (1:1) extract of air-dried aerial parts of Chiliadenus montanus afforded seven methoxylated flavonoids (1-7), three of them were isolated for the first time from the genus (1-3). Structures were established by spectroscopic methods, including HREIMS,1H,13C, DEPT,1H-1H COSY, HMQC and HMBC NMR analyses. In the present study, three of the isolated compounds were tested for the ability to induce NAD(P)H:quinoneoxidoreductase 1 (NQO1) using a quantitative bioassay in a murine hepatoma cell line. Compound 1 revealed dose-dependent NQO1 inducing properties with a concentration that doubled the specific enzyme activity by 2-fold (CD value) of 7.0 µM, and a magnitude of induction of 3.3-fold at the highest concentration tested (100 µM).

    Original languageEnglish
    Pages (from-to)788-793
    Number of pages6
    JournalJournal of Chemical and Pharmaceutical Research
    Issue number3
    Publication statusPublished - 31 Mar 2016

    ASJC Scopus subject areas

    • Pharmaceutical Science


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