Biochemical and vascular aspects of pediatric chronic fatigue syndrome

Gwen Kennedy, Faisel Khan, Alexander Hill, Christine Underwood, Jill J. F. Belch

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    Abstract

    Objective: To evaluate the biochemical and vascular aspects of pediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

    Design: Cross-sectional clinical study.

    Setting: Tayside, Scotland, United Kingdom.

    Participants: Twenty-five children with CFS/ME and 23 healthy children recruited from throughout the United Kingdom.

    Interventions: Participants underwent a full clinical examination to establish a diagnosis of CFS/ME and were asked to describe and score their CFS/ME symptoms. Biochemical markers were measured. Arterial wave reflection was estimated to assess systemic arterial stiffness.

    Main Outcome Measures: Markers of oxidative stress and free radicals, C-reactive protein level, white blood cell apoptosis, and arterial wave reflection.

    Results: Children with CFS/ME had increased oxidative stress compared with control individuals (isoprostanes: 252.30 vs 215.60 pg/mL, P =. 007; vitamin C, mean [SD]: 0.84 [0.26] vs 1.15 [0.28] mg/dL, P < .001; vitamin E, 8.72 [2.39] vs 10.94 [3.46] mu g/mL, P =. 01) and increased white blood cell apoptosis (neutrophils: 53.7% vs 35.7%, P =. 005; lymphocytes: 40.1% vs 24.6%, P =. 009). Arterial stiffness variables did not differ significantly between groups(mean augmentation index, -0.57% vs -0.47%, P =. 09); however, the derived variables significantly correlated with total (r = 0.543, P =. 02) and low-density lipoprotein (r = 0.631, P =. 004) cholesterol in patients with CFS/ME but not in controls.

    Conclusions: Biomedical anomalies seen in adults with CFS/ME-increased oxidative stress and increased white blood cell apoptosis-can also be observed in children with clinically diagnosed CFS/ME compared with matched controls. Unlike in their adult counterparts, however, arterial stiffness remained within the reference range in these pediatric patients.

    Original languageEnglish
    Pages (from-to)817-823
    Number of pages7
    JournalArchives of Pediatrics & Adolescent Medicine
    Volume164
    Issue number9
    DOIs
    Publication statusPublished - 2010

    Keywords

    • CORONARY-ARTERY-DISEASE
    • WAVE REFLECTIONS PREDICT
    • OXIDATIVE STRESS
    • CARDIOVASCULAR EVENTS
    • NEUTROPHIL APOPTOSIS
    • F-2-ISOPROSTANES
    • PRESSURE
    • INFLAMMATION
    • STIFFNESS
    • SYMPTOMS

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