Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells

Maria Sole Facioni; Joana Soares; Barabara Adinolfi; Sara Gomes; Liliana Raimundo; Adele Contini; Barbara Ruffoni; Alessia Azzarà; Arianna Tavanti; Alessandra Bertoli; Luisa Pistelli; Lucilia Saraiva; Roberto Scarpato

doi:10.1177/1934578X1801300903

Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells

Maria Sole Facioni, Joana Soares, Barabara Adinolfi, Sara Gomes, Liliana Raimundo, Adele Contini, Barbara Ruffoni, Alessia Azzarà, Arianna Tavanti, Alessandra Bertoli, Luisa Pistelli, Lucilia Saraiva, Roberto Scarpato

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4 Citations (Scopus)

Abstract

Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.

Original language	English
Pages (from-to)	1105-1110
Number of pages	6
Journal	Natural Product Communications
Volume	13
Issue number	9
DOIs	https://doi.org/10.1177/1934578X1801300903
Publication status	Published - 1 Sept 2018

Keywords

Apoptosis
Cytotoxicity
Genotoxicity
Human lymphocytes
Saponin fractions
Tumor cells

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578X1801300903

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Facioni, M. S., Soares, J., Adinolfi, B., Gomes, S., Raimundo, L., Contini, A., Ruffoni, B., Azzarà, A., Tavanti, A., Bertoli, A., Pistelli, L., Saraiva, L., & Scarpato, R. (2018). Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells. Natural Product Communications, 13(9), 1105-1110. https://doi.org/10.1177/1934578X1801300903

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abstract = "Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.",

keywords = "Apoptosis, Cytotoxicity, Genotoxicity, Human lymphocytes, Saponin fractions, Tumor cells",

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Facioni, MS, Soares, J, Adinolfi, B, Gomes, S, Raimundo, L, Contini, A, Ruffoni, B, Azzarà, A, Tavanti, A, Bertoli, A, Pistelli, L, Saraiva, L & Scarpato, R 2018, 'Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells', Natural Product Communications, vol. 13, no. 9, pp. 1105-1110. https://doi.org/10.1177/1934578X1801300903

TY - JOUR

T1 - Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells

AU - Facioni, Maria Sole

AU - Soares, Joana

AU - Adinolfi, Barabara

AU - Gomes, Sara

AU - Raimundo, Liliana

AU - Contini, Adele

AU - Ruffoni, Barbara

AU - Azzarà, Alessia

AU - Tavanti, Arianna

AU - Bertoli, Alessandra

AU - Pistelli, Luisa

AU - Saraiva, Lucilia

AU - Scarpato, Roberto

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.

AB - Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.

KW - Apoptosis

KW - Cytotoxicity

KW - Genotoxicity

KW - Human lymphocytes

KW - Saponin fractions

KW - Tumor cells

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DO - 10.1177/1934578X1801300903

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VL - 13

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JF - Natural Product Communications

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Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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