Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells

Maria Sole Facioni, Joana Soares, Barabara Adinolfi, Sara Gomes, Liliana Raimundo, Adele Contini, Barbara Ruffoni, Alessia Azzarà, Arianna Tavanti, Alessandra Bertoli, Luisa Pistelli, Lucilia Saraiva, Roberto Scarpato

Research output: Contribution to journalArticle

Abstract

Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.

Original languageEnglish
Pages (from-to)1105-1110
Number of pages6
JournalNatural Product Communications
Volume13
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • Apoptosis
  • Cytotoxicity
  • Genotoxicity
  • Human lymphocytes
  • Saponin fractions
  • Tumor cells

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    Facioni, M. S., Soares, J., Adinolfi, B., Gomes, S., Raimundo, L., Contini, A., Ruffoni, B., Azzarà, A., Tavanti, A., Bertoli, A., Pistelli, L., Saraiva, L., & Scarpato, R. (2018). Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells. Natural Product Communications, 13(9), 1105-1110. https://doi.org/10.1177/1934578X1801300903