Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases

TY - JOUR

T1 - Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases

AU - Coughtrie, Michael W.H.

AU - Sharp, Sheila

AU - Maxwell, Kaera

AU - Innes, Nicola P.

PY - 1998/2/20

Y1 - 1998/2/20

N2 - Sulfation and sulfate conjugate hydrolysis play an important role in metabolism, and are catalysed by members of the sulfotransferase and sulfatase enzyme super-families. In general, sulfation is a deactivating, detoxication pathway, but for some chemicals the sulfate conjugates are much more reactive than the parent compound. The range of compounds which are sulfated is enormous, yet we still understand relatively little of the function of this pathway. This review summarises current knowledge of the sulfation system and the enzymes involved, and illustrates how heterologous expression of sulfotransferases (SULTs) and sulfatases is aiding our appreciation of the properties of these important proteins. The role of sulfation-in the bioaetivation of procarcinogens and promutagens is discussed, and new data on the inhibition of the sulfotransferas(s) involved by common dietary components such as tea and coffee are presented. The genetic and environmental factors which are known to influence the activity and expression of human SULTs and sulfatases are also reviewed.

AB - Sulfation and sulfate conjugate hydrolysis play an important role in metabolism, and are catalysed by members of the sulfotransferase and sulfatase enzyme super-families. In general, sulfation is a deactivating, detoxication pathway, but for some chemicals the sulfate conjugates are much more reactive than the parent compound. The range of compounds which are sulfated is enormous, yet we still understand relatively little of the function of this pathway. This review summarises current knowledge of the sulfation system and the enzymes involved, and illustrates how heterologous expression of sulfotransferases (SULTs) and sulfatases is aiding our appreciation of the properties of these important proteins. The role of sulfation-in the bioaetivation of procarcinogens and promutagens is discussed, and new data on the inhibition of the sulfotransferas(s) involved by common dietary components such as tea and coffee are presented. The genetic and environmental factors which are known to influence the activity and expression of human SULTs and sulfatases are also reviewed.

KW - Sulfatases

KW - Sulfation

KW - Sulfotransferases

UR - https://www.scopus.com/pages/publications/0032549065

U2 - 10.1016/S0009-2797(97)00117-8

DO - 10.1016/S0009-2797(97)00117-8

M3 - Article

C2 - 9566730

AN - SCOPUS:0032549065

SN - 0009-2797

VL - 109

SP - 3

EP - 27

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

IS - 1-3

ER -