Biomimetic mineralization: Long-term observations in patients with dentin sensitivity

Arndt Guentsch (Lead / Corresponding author), Karin Seidler, Sandor Nietzsche, Arthur F. Hefti, Philip M. Preshaw, David C. Watts, Klaus D. Jandt, Bernd W. Sigusch

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Objective: Cervical tooth erosion is increasingly observed among adults and frequently associated with dentin sensitivity (DS). This study evaluated the effectiveness on DS of a biomimetic mineralization system (BIMIN) in comparison to the current standard treatment (Gluma ® Desensitizer, Gluma). Methods: In this single-blind, 2-arm study, 40 patients with confirmed cervical DS were randomized to either the test group or the positive control group. A Visual-Analog-Scale (VAS) was used to assess DS following stimulation of the exposed dentin with a 2-s air blast. Assessments were made at baseline (pre-treatment), 2 days, 4, 8 and 12 weeks, and 12 months after treatment. Two-stage replicas were obtained from the treated teeth and gold sputtered at baseline, and 2 days, 3 and 12 months after treatment. Surface topography of the treated cervical lesions and occlusion of dentinal tubules were investigated using scanning electron microscopy (SEM). Results: Both treatments led to a statistically significant reduction (P < 0.0001) in DS that persisted over the entire 12-month observation period. Differences in DS between the treatments were not statistically significant. SEM photomicrographs demonstrated that a mineral layer concealed the dentinal tubules in the test group. In contrast, numerous dentinal tubules remained visible in cervical defects that were treated with Gluma. Significance: A biomimetic mineralization kit was successfully used to treat patients exhibiting DS. The effect was similar to using Gluma, and was likely the result of the deposition of an enamel-like layer on the exposed cervical dentin.

Original languageEnglish
Pages (from-to)457-464
Number of pages8
JournalDental Materials
Issue number4
Publication statusPublished - Apr 2012


  • Biomaterial
  • Biomimetic mineralization
  • Dentin
  • Fluorapatite
  • Hypersensitivity

ASJC Scopus subject areas

  • General Materials Science
  • General Dentistry
  • Mechanics of Materials


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