Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes

Kenneth G. Milne; Robert A. Field; Michael A. J. Ferguson

doi:10.1007/978-1-4615-2860-9_26

Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes

Kenneth G. Milne, Robert A. Field, Michael A. J. Ferguson

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Covalent linkage to a glycosyl-phosphatidylinositol (GPI) has been widely recognised as a mode of anchoring proteins to eukaryotic cell surfaces (Ferguson and Williams, 1988; Low, 1989; Thomas et al., 1990; Cross, 1990; Ferguson, 1991). The GPI anchor can be thought of as an alternative to the hydrophobic transmembrane polypeptide domain for membrane protein anchorage. There is no clear correlation between the occurrence of a GPI anchor and protein function, examples of GPI anchored proteins include, protozoal coat proteins, hydrolases, differentiation antigens, adhesion molecules and receptors (Fig. 1). The basic structure of GPI anchors is conserved between different eukaryotes (Ferguson et al., 1988; Homans et al., 1988; Roberts et al., 1988; Schneider et al., 1990; Guther et al., 1992; Deeg et al., 1992), suggestive of a shared biosynthetic pathway.

Original language	English
Title of host publication	New developments in lipid—protein interactions and receptor function
Editors	K. W. A. Wirtz, L. Packer, J. A. Gustafsson, A. E. Evangelopoulos, J. P. Changeux
Place of Publication	New York
Publisher	Plenum Press
Pages	275-286
Number of pages	12
ISBN (Electronic)	9781461528609
ISBN (Print)	9781461362395
DOIs	https://doi.org/10.1007/978-1-4615-2860-9_26
Publication status	Published - 1993
Event	NATO Advanced Study Institute on New Developments in Lipid-Protein Interactions and Receptor Function Conference - Spetsai, Greece Duration: 16 Aug 1992 → 27 Aug 1992 http://www.worldcat.org/title/new-developments-in-lipid-protein-interactions-and-receptor-function-proceedings-of-a-nato-advanced-study-institute-on-new-developments-in-lipid-proteinand-receptor-function-held-august-16-27-1992-in-spetsai-greece/oclc/311928225

Publication series

Name	NATO ASI series. Series A: Life sciences
Volume	246

Conference

Conference	NATO Advanced Study Institute on New Developments in Lipid-Protein Interactions and Receptor Function Conference
Country/Territory	Greece
City	Spetsai
Period	16/08/92 → 27/08/92
Internet address	http://www.worldcat.org/title/new-developments-in-lipid-protein-interactions-and-receptor-function-proceedings-of-a-nato-advanced-study-institute-on-new-developments-in-lipid-proteinand-receptor-function-held-august-16-27-1992-in-spetsai-greece/oclc/311928225

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10.1007/978-1-4615-2860-9_26

Cite this

Milne, K. G., Field, R. A., & Ferguson, M. A. J. (1993). Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes. In K. W. A. Wirtz, L. Packer, J. A. Gustafsson, A. E. Evangelopoulos, & J. P. Changeux (Eds.), New developments in lipid—protein interactions and receptor function (pp. 275-286). (NATO ASI series. Series A: Life sciences; Vol. 246). Plenum Press. https://doi.org/10.1007/978-1-4615-2860-9_26

Milne, Kenneth G. ; Field, Robert A. ; Ferguson, Michael A. J. / Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes. New developments in lipid—protein interactions and receptor function . editor / K. W. A. Wirtz ; L. Packer ; J. A. Gustafsson ; A. E. Evangelopoulos ; J. P. Changeux. New York : Plenum Press, 1993. pp. 275-286 (NATO ASI series. Series A: Life sciences).

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title = "Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes",

abstract = "Covalent linkage to a glycosyl-phosphatidylinositol (GPI) has been widely recognised as a mode of anchoring proteins to eukaryotic cell surfaces (Ferguson and Williams, 1988; Low, 1989; Thomas et al., 1990; Cross, 1990; Ferguson, 1991). The GPI anchor can be thought of as an alternative to the hydrophobic transmembrane polypeptide domain for membrane protein anchorage. There is no clear correlation between the occurrence of a GPI anchor and protein function, examples of GPI anchored proteins include, protozoal coat proteins, hydrolases, differentiation antigens, adhesion molecules and receptors (Fig. 1). The basic structure of GPI anchors is conserved between different eukaryotes (Ferguson et al., 1988; Homans et al., 1988; Roberts et al., 1988; Schneider et al., 1990; Guther et al., 1992; Deeg et al., 1992), suggestive of a shared biosynthetic pathway.",

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year = "1993",

doi = "10.1007/978-1-4615-2860-9_26",

language = "English",

isbn = "9781461362395",

series = "NATO ASI series. Series A: Life sciences",

publisher = "Plenum Press",

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editor = "Wirtz, {K. W. A.} and L. Packer and Gustafsson, {J. A.} and Evangelopoulos, {A. E.} and Changeux, {J. P.}",

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note = "NATO Advanced Study Institute on New Developments in Lipid-Protein Interactions and Receptor Function Conference ; Conference date: 16-08-1992 Through 27-08-1992",

url = "http://www.worldcat.org/title/new-developments-in-lipid-protein-interactions-and-receptor-function-proceedings-of-a-nato-advanced-study-institute-on-new-developments-in-lipid-proteinand-receptor-function-held-august-16-27-1992-in-spetsai-greece/oclc/311928225",

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Milne, KG, Field, RA & Ferguson, MAJ 1993, Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes. in KWA Wirtz, L Packer, JA Gustafsson, AE Evangelopoulos & JP Changeux (eds), New developments in lipid—protein interactions and receptor function . NATO ASI series. Series A: Life sciences, vol. 246, Plenum Press, New York, pp. 275-286, NATO Advanced Study Institute on New Developments in Lipid-Protein Interactions and Receptor Function Conference, Spetsai, Greece, 16/08/92. https://doi.org/10.1007/978-1-4615-2860-9_26

Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes. / Milne, Kenneth G.; Field, Robert A.; Ferguson, Michael A. J.
New developments in lipid—protein interactions and receptor function . ed. / K. W. A. Wirtz; L. Packer; J. A. Gustafsson; A. E. Evangelopoulos; J. P. Changeux. New York: Plenum Press, 1993. p. 275-286 (NATO ASI series. Series A: Life sciences; Vol. 246).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes

AU - Milne, Kenneth G.

AU - Field, Robert A.

AU - Ferguson, Michael A. J.

PY - 1993

Y1 - 1993

N2 - Covalent linkage to a glycosyl-phosphatidylinositol (GPI) has been widely recognised as a mode of anchoring proteins to eukaryotic cell surfaces (Ferguson and Williams, 1988; Low, 1989; Thomas et al., 1990; Cross, 1990; Ferguson, 1991). The GPI anchor can be thought of as an alternative to the hydrophobic transmembrane polypeptide domain for membrane protein anchorage. There is no clear correlation between the occurrence of a GPI anchor and protein function, examples of GPI anchored proteins include, protozoal coat proteins, hydrolases, differentiation antigens, adhesion molecules and receptors (Fig. 1). The basic structure of GPI anchors is conserved between different eukaryotes (Ferguson et al., 1988; Homans et al., 1988; Roberts et al., 1988; Schneider et al., 1990; Guther et al., 1992; Deeg et al., 1992), suggestive of a shared biosynthetic pathway.

AB - Covalent linkage to a glycosyl-phosphatidylinositol (GPI) has been widely recognised as a mode of anchoring proteins to eukaryotic cell surfaces (Ferguson and Williams, 1988; Low, 1989; Thomas et al., 1990; Cross, 1990; Ferguson, 1991). The GPI anchor can be thought of as an alternative to the hydrophobic transmembrane polypeptide domain for membrane protein anchorage. There is no clear correlation between the occurrence of a GPI anchor and protein function, examples of GPI anchored proteins include, protozoal coat proteins, hydrolases, differentiation antigens, adhesion molecules and receptors (Fig. 1). The basic structure of GPI anchors is conserved between different eukaryotes (Ferguson et al., 1988; Homans et al., 1988; Roberts et al., 1988; Schneider et al., 1990; Guther et al., 1992; Deeg et al., 1992), suggestive of a shared biosynthetic pathway.

U2 - 10.1007/978-1-4615-2860-9_26

DO - 10.1007/978-1-4615-2860-9_26

M3 - Conference contribution

SN - 9781461362395

T3 - NATO ASI series. Series A: Life sciences

SP - 275

EP - 286

BT - New developments in lipid—protein interactions and receptor function

A2 - Wirtz, K. W. A.

A2 - Packer, L.

A2 - Gustafsson, J. A.

A2 - Evangelopoulos, A. E.

A2 - Changeux, J. P.

PB - Plenum Press

CY - New York

T2 - NATO Advanced Study Institute on New Developments in Lipid-Protein Interactions and Receptor Function Conference

Y2 - 16 August 1992 through 27 August 1992

ER -

Milne KG, Field RA, Ferguson MAJ. Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes. In Wirtz KWA, Packer L, Gustafsson JA, Evangelopoulos AE, Changeux JP, editors, New developments in lipid—protein interactions and receptor function . New York: Plenum Press. 1993. p. 275-286. (NATO ASI series. Series A: Life sciences). doi: 10.1007/978-1-4615-2860-9_26

Biosynthesis of glycosyl-phosphatidylinositol protein snchors in African trypanosomes

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