Birth order and risk for schizophrenia: a 31-year follow-up of the Northern Finland 1966 Birth Cohort

L Kemppainen; J Veijola; J Jokelainen; A-L Hartikainen; M-R Järvelin; P Jones; T Croudace; M Isohanni

doi:10.1034/j.1600-0447.2001.00258.x

Birth order and risk for schizophrenia: a 31-year follow-up of the Northern Finland 1966 Birth Cohort

L Kemppainen (Lead / Corresponding author), J Veijola, J Jokelainen, A-L Hartikainen, M-R Järvelin, P Jones, T Croudace, M Isohanni

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Objective: The Northern Finland 1966 Birth Cohort was studied in order to investigate the association between birth order and schizophrenia.
Method: Four categories of birth order status (first-born, last-born, onlychild and other status) were formed and linked to data on psychiatricmorbidity. Effects were adjusted for wantedness of pregnancy, perinatalcomplications, maternal age at delivery, family type and number ofsiblings.
Results: The risk for schizophrenia was elevated among male first-borns(ratio 1.5; 95% CI 1.0-2.2) and female last-borns (ratio 1.3; 95% CI 0.9-1.9). The risk was lower than expected among male last-borns (ratio 0.7;95% CI 0.5-0.9) and females belonging to other status (ratio 0.6; 95% CI 0.3-0.9).
Conclusion: These results suggest that specic birth order status is anindependent risk factor for schizophrenia. Theoretical explanations mayarise from biological factors unidentied here and/or psychologicalstressors linked with these positions.

Original language	English
Pages (from-to)	148-152
Number of pages	5
Journal	Acta Psychiatrica Scandinavica
Volume	104
Issue number	2
DOIs	https://doi.org/10.1034/j.1600-0447.2001.00258.x
Publication status	Published - Aug 2001

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title = "Birth order and risk for schizophrenia: a 31-year follow-up of the Northern Finland 1966 Birth Cohort",

abstract = "Objective: The Northern Finland 1966 Birth Cohort was studied in order to investigate the association between birth order and schizophrenia.Method: Four categories of birth order status (first-born, last-born, onlychild and other status) were formed and linked to data on psychiatricmorbidity. Effects were adjusted for wantedness of pregnancy, perinatalcomplications, maternal age at delivery, family type and number ofsiblings.Results: The risk for schizophrenia was elevated among male first-borns(ratio 1.5; 95% CI 1.0-2.2) and female last-borns (ratio 1.3; 95% CI 0.9-1.9). The risk was lower than expected among male last-borns (ratio 0.7;95% CI 0.5-0.9) and females belonging to other status (ratio 0.6; 95% CI 0.3-0.9).Conclusion: These results suggest that specic birth order status is anindependent risk factor for schizophrenia. Theoretical explanations mayarise from biological factors unidentied here and/or psychologicalstressors linked with these positions.",

author = "L Kemppainen and J Veijola and J Jokelainen and A-L Hartikainen and M-R J{\"a}rvelin and P Jones and T Croudace and M Isohanni",

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T2 - a 31-year follow-up of the Northern Finland 1966 Birth Cohort

AU - Kemppainen, L

AU - Veijola, J

AU - Jokelainen, J

AU - Hartikainen, A-L

AU - Järvelin, M-R

AU - Jones, P

AU - Croudace, T

AU - Isohanni, M

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N2 - Objective: The Northern Finland 1966 Birth Cohort was studied in order to investigate the association between birth order and schizophrenia.Method: Four categories of birth order status (first-born, last-born, onlychild and other status) were formed and linked to data on psychiatricmorbidity. Effects were adjusted for wantedness of pregnancy, perinatalcomplications, maternal age at delivery, family type and number ofsiblings.Results: The risk for schizophrenia was elevated among male first-borns(ratio 1.5; 95% CI 1.0-2.2) and female last-borns (ratio 1.3; 95% CI 0.9-1.9). The risk was lower than expected among male last-borns (ratio 0.7;95% CI 0.5-0.9) and females belonging to other status (ratio 0.6; 95% CI 0.3-0.9).Conclusion: These results suggest that specic birth order status is anindependent risk factor for schizophrenia. Theoretical explanations mayarise from biological factors unidentied here and/or psychologicalstressors linked with these positions.

AB - Objective: The Northern Finland 1966 Birth Cohort was studied in order to investigate the association between birth order and schizophrenia.Method: Four categories of birth order status (first-born, last-born, onlychild and other status) were formed and linked to data on psychiatricmorbidity. Effects were adjusted for wantedness of pregnancy, perinatalcomplications, maternal age at delivery, family type and number ofsiblings.Results: The risk for schizophrenia was elevated among male first-borns(ratio 1.5; 95% CI 1.0-2.2) and female last-borns (ratio 1.3; 95% CI 0.9-1.9). The risk was lower than expected among male last-borns (ratio 0.7;95% CI 0.5-0.9) and females belonging to other status (ratio 0.6; 95% CI 0.3-0.9).Conclusion: These results suggest that specic birth order status is anindependent risk factor for schizophrenia. Theoretical explanations mayarise from biological factors unidentied here and/or psychologicalstressors linked with these positions.

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JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

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Birth order and risk for schizophrenia: a 31-year follow-up of the Northern Finland 1966 Birth Cohort

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