Blood flow changes in diabetic foot ulcers treated with dermal replacement therapy

D. J. Newton, F. Khan, J. J. F. Belch, M. R. Mitchell, G. P. Leese

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    The study investigated whether the effects of dermal replacement therapy on wound healing are associated with an increase in blood flow at the base of diabetic foot ulcers treated with Dermagraft. Seven full-thickness ulcers were assessed in five patients with type 2 diabetes mellitus and peripheral neuropathy. All lesions had been present for at least 3 months with no recent change in size, despite routine foot care and protective dressings. Dermal replacement therapy was applied weekly to the base of each wound for 8 weeks, after which regular dressing was resumed. Microvascular blood flow was assessed using laser Doppler imaging immediately before and after 2, 5, and 8 weeks of treatment. Blood flow increased by an average of 72% in the base of five out of the seven ulcers studied. Five of the lesions healed by 12 weeks and the other two reduced in size by approximately 25%. The changes in blood flow observed in this pilot study might reflect angiogenesis in the newly formed granulation tissue and/or vasodilatation of existing vessels, processes that are possibly enhanced by the intervention.
    Original languageEnglish
    Pages (from-to)233-237
    Number of pages5
    JournalJournal of Foot and Ankle Surgery
    Volume41
    Issue number4
    DOIs
    Publication statusPublished - 2002

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    Diabetic Foot
    Skin
    Bandages
    Ulcer
    Granulation Tissue
    Peripheral Nervous System Diseases
    Therapeutics
    Vasodilation
    Wound Healing
    Type 2 Diabetes Mellitus
    Foot
    Lasers
    Wounds and Injuries

    Cite this

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    title = "Blood flow changes in diabetic foot ulcers treated with dermal replacement therapy",
    abstract = "The study investigated whether the effects of dermal replacement therapy on wound healing are associated with an increase in blood flow at the base of diabetic foot ulcers treated with Dermagraft. Seven full-thickness ulcers were assessed in five patients with type 2 diabetes mellitus and peripheral neuropathy. All lesions had been present for at least 3 months with no recent change in size, despite routine foot care and protective dressings. Dermal replacement therapy was applied weekly to the base of each wound for 8 weeks, after which regular dressing was resumed. Microvascular blood flow was assessed using laser Doppler imaging immediately before and after 2, 5, and 8 weeks of treatment. Blood flow increased by an average of 72{\%} in the base of five out of the seven ulcers studied. Five of the lesions healed by 12 weeks and the other two reduced in size by approximately 25{\%}. The changes in blood flow observed in this pilot study might reflect angiogenesis in the newly formed granulation tissue and/or vasodilatation of existing vessels, processes that are possibly enhanced by the intervention.",
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    Blood flow changes in diabetic foot ulcers treated with dermal replacement therapy. / Newton, D. J.; Khan, F.; Belch, J. J. F.; Mitchell, M. R.; Leese, G. P.

    In: Journal of Foot and Ankle Surgery , Vol. 41, No. 4, 2002, p. 233-237.

    Research output: Contribution to journalArticle

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    AU - Newton, D. J.

    AU - Khan, F.

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    AU - Mitchell, M. R.

    AU - Leese, G. P.

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    AB - The study investigated whether the effects of dermal replacement therapy on wound healing are associated with an increase in blood flow at the base of diabetic foot ulcers treated with Dermagraft. Seven full-thickness ulcers were assessed in five patients with type 2 diabetes mellitus and peripheral neuropathy. All lesions had been present for at least 3 months with no recent change in size, despite routine foot care and protective dressings. Dermal replacement therapy was applied weekly to the base of each wound for 8 weeks, after which regular dressing was resumed. Microvascular blood flow was assessed using laser Doppler imaging immediately before and after 2, 5, and 8 weeks of treatment. Blood flow increased by an average of 72% in the base of five out of the seven ulcers studied. Five of the lesions healed by 12 weeks and the other two reduced in size by approximately 25%. The changes in blood flow observed in this pilot study might reflect angiogenesis in the newly formed granulation tissue and/or vasodilatation of existing vessels, processes that are possibly enhanced by the intervention.

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