Bovine Serum Albumin (BSA)/polyacrylonitrile (PAN) biohybrid nanofibers coated with a biomineralized calcium deficient hydroxyapatite (HA) shell for wound dressing

Shahin Homaeigohar (Lead / Corresponding author), Ting-Yu Tsai, Eman S. Zaire, Mady Elbahri, Tai-Horng Young, Aldo R. Boccaccini

Research output: Contribution to journalArticle

Abstract

Here, for the first time, a nanofibrous (NF) wound dressing comprising biomineralized polyacrylonitrile (PAN) nanofibers is developed. In contrast to the majority of the currently available nanofibrous wound dressings that are based on natural polymers, PAN is a synthetic, industrial polymer, which has been rarely considered for this purpose. PAN NFs are first hydrolyzed to allow for tethering of biofunctional agents (here Bovine Serum Albumin (BSA)). Later, the biofunctionlized PAN NFs are biomineralized by immersion in simulated body fluid (SBF). As a result, core-shell, calcium deficient hydroxyapatite (HA)/BSA/PAN nanofibers form, that are mechanically stronger (elastic modulus; 8.5 vs. 6 MPa) compared to the untreated PAN NFs. The biomineralized PAN NFs showed promising bioactivity as reflected in the cell biology tests with fibroblast and keratinocyte cells. Hs68 fibroblasts and HaCat keratinocytes were found to be more viable in the presence of the biomineralized NFs than when they were co-cultured with the neat PAN NFs. Such mechanical and biological characteristics of the biomineralized PAN NFs are favorable for wound dressing applications.

Original languageEnglish
Article number111248
JournalMaterials Science and Engineering C
Volume116
Early online date2 Jul 2020
DOIs
Publication statusE-pub ahead of print - 2 Jul 2020

Keywords

  • Biofunctionalization
  • Biomineralization
  • Nanofiber
  • Polyacrylonitrile (PAN)
  • Wound dressing

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