Brain natriuretic peptide: Effect on left ventricular filling patterns in healthy subjects

P. B. M. Clarkson, N. M. Wheeldon, C. MacLeod, W. Coutie, T. M. MacDonald

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


1. Elevated plasma concentrations of brain natriuretic peptide are found in conditions associated with impaired left ventricular diastolic function. The purpose of this study was to determine whether this peptide actually plays a physiological role in improving myocardial performance in diastole, 2. Nine normal subjects received infusions of brain natriuretic peptide or placebo in a randomized, double-blind, crossover study, Brain natriuretic peptide infusion produced a significant reduction in isovolumic relaxation time (means and 95% confidence interval for difference -10.8 ms, -14.5 to -7.0 ms) (P < 0.01) and significantly increased both the peak E/A velocity (0.54, 0.14-0.94) (P < 0.05) and the E/A time velocity integral (1.09, 0.20-1.98) (P < 0.05). 3. These responses were evident at concentrations of brain natriuretic peptide that produced no associated effects on blood pressure, heart rate or stroke distance, 4. Brain natriuretic peptide infusion in normal subjects significantly reduces isovolumic relaxation time and improves transmitral Doppler flow profiles, suggesting that this peptide may be important in the control of left ventricular diastolic relaxation in man.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalClinical Science
Issue number2
Publication statusPublished - 1 Feb 1995


  • Brain natriuretic peptide
  • Doppler echocardiography
  • Left ventricle

ASJC Scopus subject areas

  • Medicine(all)


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